摘要
目的了解章丘市≤15岁健康人群埃可病毒30型(ECHO30)的人群感染情况.方法用中和抗体检测技术测定血清抗体水平.结果章丘市存在ECHO30所致无菌性脑膜炎的爆发,≤15岁健康人群中和抗体几何平均滴度(GMT)为1:53.08,非常显著地高于非流行区的GMT(1:32.45).流行区中和抗体滴度集中分布在1:64～1:256(36.52%),年龄别抗体水平有差异,≥3岁人群随着年龄的增长,抗体水平呈下降趋势.非流行区人群血清中和抗体水平无年龄别差异.结论 ECHO30所致疾病流行后,人群具有一定的免疫力;非流行区未出现该毒株所致疾病的流行.
Objective To precisely describe the infection status of ECHO30 in healthy children under 15 years old in Shandong Province, especially in Zhangqiu City. Methods To test the level of sera neutralization antibody depends on the technology of neutralization test. Results An outbreak of asep- tic meningitis caused by ECHO30 existed in Zhangqiu City, and the type specific neutralizing antibody titer of epidemic area was higher than that of non-epidemic area in children under 15 years old, geo- metric mean titer （GMT） were 1 ： 53.08 and 1 ： 32.45, respectively, the antibody titer distribution of case group concentrate from 1：64 - 1：256, and there was divergence among the age specific groups, the antibody titers descended with the up of age specific groups upwards of 3 years old group in case group. There was no divergence of antibody titers among the age specific groups in non-epidemic area, similarly to the sex specific groups. Conclusion It showed that population immunity was elevated after an epidemic of infectious disease, and there was no epidemic of that disease caused by ECHO30 in non-epidemic areas.
出处
《中国计划免疫》
2005年第6期461-464,共4页
Chinese Journal of Vaccines and Immunization
