摘要
目的探讨经鼻面罩双水平气道正压(BiPAP)通气在慢性阻塞性肺疾病(COPD)合并急性呼吸衰竭早期的应用价值。方法将80例COPD合并急性呼衰患者分为2组,每组40例,在进行抗感染、对症等常规治疗的同时,分别给予持续静滴可拉明及经鼻面罩BiPAP通气治疗6小时,判断两组之间治疗前后生命体症及血气分析变化。结果两组治疗6小时后,机械通气组在血压、心率、呼吸频率方面改善均显著优于对照组(P<0.01);对照组pH值无改善,而机械通气组pH值显著改善,与对照组相比有显著差异(P<0.01);机械通气组和对照组治疗后均有PaO2上升和PaCO2下降,但机械通气组改善更明显,与对照组相比有显著差异(P<0.01)。结论经鼻面罩BiPAP通气适合治疗COPD合并急性呼衰患者,其在改善临床症状和动脉血气指标方面均优于常规治疗,值得临床推广。
Objective To determine the efficacy of Nasal mask Bi-level positive airway pressure （BiPAP） ventilation in early-staged chronic obstructive pulmonary disease （COPD） with acute respiratory failure. Methods 80 cases of early-staged COPD accompanied by acute respiratory failure were divided into two groups： coramine was added to conventional management in 40casese of control, and 6 hours of nasal mask Bi-PAP ventilation was added to conventional management in 40 cases of Bi-PAP group. Vital Signs and blood gas analysis were evaluated. Results After 6 hours of treatment, blood pressure,heart rate and respiratory frequency were significantly improved in Bi-PAP group than coutrol. Compared with control, there was a significant improvement in pH in Bi-PAP group （ P〈0.01）. Increase in PaO2 and decrease in PaCO2 were found in both groups,amplitudes of PaO2 and PaCO2 before and after treatment were greater in Bi-PAP group of （MV） than control （ P 〈 0.01）. Conclusions Nasal mask Bi-PAP ventilation in earlystaged COPD accompanied with acute respiratory failure improves gas exchange and symptoms more significantly than conventional management.
出处
《国外医学（呼吸系统分册）》
2005年第12期888-890,共3页
Section of Respiratory System Foreign Medical Sciences
关键词
慢性阻塞性肺疾病
呼吸衰竭
双水平气道正压
Chronic obstructive pulmonary disease
Respiratory failure
Bi-level positive airway pressure
