摘要
用非离子表面活性剂和胆固醇为原料,采用薄膜分散法制备甲氨蝶呤囊泡,通过透析法分离未包封的药物,紫外分光光度法测定包封率和体外释药性。结果显示,Span 60与胆固醇形成的囊泡(VSpan 60∶VCHOL=5∶3),在50℃超声40 m in的条件下,对0.60 g/L的甲氨蝶呤包封率可达65%以上,在模拟胃流体和模拟肠流体中均有良好的缓释作用。
The methotrexate niosomes was prepared by non-ionic surfactant and cholesterol by aqueous dispersion of film. The free methotrexate was removed by dialysis. Entrapment efficiency and release of methotrexate from niosomes in vitro were measured by ultraviolet spectrophotometry. The results show that the entrapment efficiency of the niosomes prepared by span 60 and cholesterol （ VSpan 60：VCHOL= 5 ： 3 ） is more than 65% for methotrexate. The release profiles in simulated gastric and intestinal fluid showed a controlled release tendency to some extent.
出处
《应用化工》
CAS
CSCD
2005年第12期757-759,共3页
Applied Chemical Industry
关键词
甲氨蝶呤
非离子表面活性剂
囊泡
制备
缓释性
methotrexate
non-ionic surfactant
niosomes
preparation
sustained-release
