摘要
目的观察水盐限制联合利尿治疗对CAPD患者容量超负荷的疗效。方法第四军医大学西京医院血液净化中心CAPD52例符合条件的患者随机分为A、B两组,A组单纯水盐限制,B组在水盐限制的基础上,加服速尿120～240mg/日,分2次口服,检测治疗前及治疗1月后体重、平均动脉压、尿量、超滤量、浮肿程度、心胸比例等变化。结果①较治疗前相比,A组的体重、平均动脉压、心胸比例均有所前下降,但无统计学意义,平均尿量和平均超滤量无变化。B组的体重、平均动脉压、平均尿量、心胸比例均较治疗前明显下降(P<0.05),其中体重和平均尿量在两组间差异具有显著性(P<0.05);②两组的水肿程度均有不同程度的下降,B组更为明显。③A组总有效率为53.8%,B组总有效率为84.7%。两组相比总有效率差异有统计学意义(P<0.05)。结论单纯限制水盐摄入或联用利尿治疗均能改善CAPD患者容量超负荷状况,但后者的效果更明显,水盐限制基础上加用利尿是治疗CAPD患者容量超负荷的安全有效的方法。
Objective To study the effect of the salt and water restriction combined with diuretics therapy on fluid status in patients on continuous ambulatory peritoneal dialysis （CAPD）. Methods 52 patients were randomly divided into two groups： the salt and water restriction group（group A） and salt and water restriction combined with diuretics treatment group （group B）. Body weights, mean arterial pressure, urine volume and ultra filtration volume were measured before and i month after the treatments in both groups. Resuks ①In group A, body weights, mean arterial pressure, cardiothoracic ratio of patients were slightly decreased without significance compared to those taken before treatment, while the urine volume and peritoneal ultrafiltration volume were not change; In group B, body weights, mean arterial pressure,urine volume of the patients were notably decreased compared to those taken before treatment; The urine volume was significantly increased, and the body weights was markedly decreased in group B than in group A after the treatment;②Edema of patients in two groups was both alleviated with great degree in group B;③There was markedly difference in total efficient rate between two groups with the efficient rate in group A 53.8% and 84.7% in group B. Conclusions The salt and water restriction combined with diuretics therapy may be a safe and effective method to relieve fluid overload in patients on continuous ambulatory peritoneal dialysis.
出处
《中国血液净化》
2005年第12期646-648,共3页
Chinese Journal of Blood Purification
