摘要
目的:研究依达拉奉对急性脑缺血再灌注损伤的保护作用。方法:将108只SD大鼠分成生理盐水组和依达拉奉高剂量组(1 mg)及低剂量组(0.5 mg),每组再各分为1 h,6 h及24 h组,每组12只。采用线栓法制造大鼠大脑中动脉再灌注模型,将依达拉奉生理盐水溶液于造模后1,6,24 h注入大鼠股静脉中,1周后断头取脑,组织做病理切片并计算梗死体积。结果:依达拉奉高剂量组(1 mg)、依达拉奉低剂量组(0.5 mg)、对照组坏死体积依次明显减少。结论:依达拉奉对脑缺血再灌注损伤组织有明显保护作用。
AIM： To investigate the protective effect of edaravone on cerebral ischemia. METHODS： 72 Sprague-Dawley （SD） rats were randomly divided into 3 groups： physiological saline group, edaravone group （1 mg） and edaravone group（0.5 mg）. Then they were each divided into 3 subgroups（ 1 h, 6 h,24 h）. Then local cerebral ischemic reperfusion model was made with thread embolism of left middle cerebral artery （MCA） of male SD rats. Edaravone was dissolved in physiological saline and injected intravenously in the model of SD rats. Cerebral infartion volumes were calculated with computer tomography after a week. RESULTS： Edaravone can effectively reduce infartion volumes in brains after male SD rats ischemia and reperfusion. CONCLUSION： Edaravone can effectively protect brain after cerebral ischemia and can thus treat local reperfusion injury.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2005年第6期577-579,共3页
Journal of China Pharmaceutical University
关键词
依达拉奉
脑缺血
保护
Edaravone
Cerebral ischemia
Protection
