摘要
目的探讨高血压及并发症患者的血浆内皮素水平与高血压发病的关系。方法采用放免法（ＲＩＡ）测定高血压及其合并冠心病、心肌梗塞、脑梗塞、肾病患者的血浆内皮素水平并与正常人对比。结果高血压患者血浆内皮素水平明显升高（Ｐ＜０．０５），并与舒张压呈正相关（ｒ＝０．３９６Ｐ＜０．０５，ｎ＝３６），当合并有冠心病及肾病时升高显著（Ｐ＜０．０１），合并有心肌梗塞及脑梗塞时升高更为显著（Ｐ＜０．００２）。结论高血压并发冠心病、肾病、心肌梗塞和脑梗塞患者的血浆ＥＴ水平均较正常组升高，硝苯地平、卡托普利。
Aim\ To investigate the changes of plasma endothelin(ET) in hypertension. Methods\ The plasma ET level was measured by radioimmunoassay in hypertension patients or hypertension complicated with coronary heart disease, myocardial infarction,cerebral infarction or renal lesions. Results\ The plasma ET level was significantly elevated in the hypertension patients(P<0 05) and the elevation was positively correlated with the diastolic pressure(r=0 396,P<0 05,n=36) The ET concentration increased apparently when hypertension complicated with coronary heart disease and renal damage(P<0 01). But the most significent elevation occured in the patients with myocardial infarction or cerebral infarction(P<0 002). The anti hypertension drugs such as nifedipine, captopril and metoprolol have no apparent effect on the plasma ET level in the hypertension patients(P>0 05).
出处
《高血压杂志》
CSCD
1996年第3期217-218,共2页
Chinese Journal of Hypertension
关键词
高血压
内皮素
并发症
hypertension\ endothelin\ complication
