摘要
目的液相合成Trp-Met-Asp-PheNH2四肽(CCK-4)。方法以N-保护的色氨酸、甲硫氨酸、天门冬氨酸和C-保护的苯丙氨酸为原料,采用混合酸酐法合成了CCK四肽,总收率38.5%。结果其结构经IR、1HNMR、MS确证,熔点与文献报道的一致。结论采用重复过量混合酸酐法合成了目标化合物(6),所用方法经济、有效、可靠。
OBJECTIVE To synthesize of Trp - Met - Asp - PheNH2 tetrapeptides （ CCK - 4）. METHODS The CCK - 4 peptides were condensed from N - protected Trp, Met, Asp and C - protected Phe by Mixture anhydrides method, resulting in total yield of 38.5 %. RESULTS The structure of the compound was confirmed by spectral data of IR, I HNMR and MS. CONCLUSION The synthesis of target compound 6 was by mixture anhydrides method. The result shows that the method of the synthesis of CCK - 4 is an efficient and economical method.
出处
《华西药学杂志》
CAS
CSCD
北大核心
2005年第6期518-520,共3页
West China Journal of Pharmaceutical Sciences
基金
国家自然科学基金资助项目(批准号:20472055)
关键词
多肽
CCK-4
混合酸酐法
液相合成
Peptides
CCK-4
Mixture anhydrides method
Liquid phase synthesis
