摘要
目的:观察川芎嗪辅助治疗毛细支气管炎的疗效,探讨其减少心衰并发症的机制。方法:将临床确诊的毛细支气管炎95例,随机分为对照组46例,采用抗病毒、吸氧、镇静、平喘及对症支持治疗,治疗组49例在对照组治疗基础上加用川芎嗪治疗5mg/(kg·d),1次/d,连用5d。比较组间7日治愈率及心力衰竭发生率。结果:治疗组治愈率(88%)明显优于对照组(65%),两组相比差异显著(P<0.01)。而治疗组心力衰竭并发症有下降趋势,仅出现2例(4%),低于对照组7例(15%)。结论:早期应用川芎嗪佐治毛细支气管炎可提高治愈率并减少心衰并发症,缩短病程。
Objective： To observe the curative effect of ligustrazin on early bronchiolitis and study the mechanism about how it decreases the congestive heart failure （CHF）. Methods： 95 cases with clinic diagnosis of bronchiolitis were randomly divided into 2 groups： 46 cases in the control group received the treatments of antivirus, oxygen inhalation, conscious-sedation and symptomatic treatment. Besides all these the other 49 cases of treatment group had used ligustrazin, 5 mg/（kg·d）, one time a day, for 5 days. Curative rates after seven-day treatment and CHF rates were compared. Results： The cure rate of treatment group （88%） was obviously higher than that of control group （65%）, showing a significant difference between 2 groups （P 〈 0.01 ）. There were 2 cases （4%） of CHF in treatment group, lower than in control group （7 cases, 15%）. Conclusions： Using ligustrazin on early bronchiolitis can decrease the CHF and increase cure rate and shorten the disease course.
出处
《儿科药学杂志》
CAS
2005年第6期36-37,共2页
Journal of Pediatric Pharmacy
关键词
川芎嗪
毛佃支气管炎
心力衰竭
Ligustrazin
Bronehiolitis
Congestive heart failure
