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淋巴细胞性垂体炎的MRI表现 被引量:28

MRI of lymphocytic hypophysitis
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摘要 目的描述淋巴细胞性垂体炎的MRI表现,探讨MRI的诊断价值和限度及其与垂体腺瘤的鉴别诊断。方法对5例临床以多饮、多尿及头痛为主要症状前来就诊,手术病理诊断为淋巴细胞性垂体炎患者的术前MR影像及其临床资料进行回顾性分析。结果5例淋巴细胞性垂体炎患者MRI均表现为垂体增大,垂体蒂增粗,正常神经垂体T1WI高信号消失,病变均呈明显强化,其中2例为均匀强化,3例强化不均匀。2例可见海绵窦及相邻硬脑膜受侵犯。结论对于垂体增大合并中枢性尿崩症,伴或不伴有腺垂体功能低下的患者要考虑淋巴细胞性垂体炎的诊断。 Objective To describe the MR findings in patients with lymphocytic hypophysitis (LyH), and to discuss MR diagnostic value and limit in this disease entity and its differentiation with pituitary adenoma. Methods Five pathologically proven cases of LyH were recruited in this study. The main complaints of the patients were polydipsia, polyuria, and headache. The preoperative MR images and clinical manifestations were analyzed retrospectively. Results MR findings of the 5 patients with LyH included enlargement of pituitary gland, stalk thickening, disappearance of high signal of neurohypophysis on T1WI, and marked Gadolinium enhancement of the lesions. Homogeneous enhancement was found in 2 cases, while heterogeneous enhancement was in 3 cases. Involvement of the cavernous sinus and dura mater on dorsum sella and clivus were found in 2 patients. Conclusion The diagnosis of LyH should be suggested when the enlarged pituitary gland is associated with central diabetes insipidus, and with/without dysfunction of adenohypophysis.
出处 《中华放射学杂志》 CAS CSCD 北大核心 2005年第11期1198-1200,共3页 Chinese Journal of Radiology
关键词 垂体疾病 炎症 磁共振成像 淋巴细胞性垂体炎 MRI Pituitary disease Inflammation Magnetic resonance imaging
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参考文献6

  • 1Leung GK, Lopes MB, Thorner MO, et al. Primary hypophysitis: a single-center experience in 16 cases. J Neurosurg, 2004,101:262-271.
  • 2Flanagan DE, Ibrahim AE, Ellison DW, et al. Inflammatory hypophysitis-the spectrum of disease. Acta Neurochir (Wien),2002,144:47 -56.
  • 3张志魁,刘洁,杨守京,晏培松,李青,马福成,王映梅.淋巴细胞性垂体炎1例[J].诊断病理学杂志,2003,10(2):87-87. 被引量:4
  • 4Hashimoto K, Takao T, Makino S. Lymphocytic adenohypophysitis and lymphocytic infundibuloneurohypophysitis. Endocrine Journal,1997, 44:1-10.
  • 5Bellastella A, Bizzarro A, Coronella C, et al. Lymphocytic hypophysitis: a rare or underestimated disease? Eur J Endocrinol,2003, 149:363-376.
  • 6Nakamura Y, Okada H, Wada Y, et al. Lymphocytic hypophysitis:its expanding features. J Endocrinol Invest, 2001,24:262-267.

二级参考文献2

  • 1Topliss DJ, Volpe R.Lymphocytic hypophysitis.Ann Intern Med, 1981,95:227.
  • 2Bettendorf M, Fehn M, Grulich Henn Jet al . Lymphocytic hypophysitis with central diabetes insipidus and consequent panhypopituitarism preceding a multifocal intracranial greminoma in a prepubertal girl. Eur J Pediatr, 1999,158:288.

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