摘要
目的:探讨消化道肿瘤以5-FU为基础的联合化疗方案引起化疗相关性腹泻(Chemotherapy-induced diarrhea,CID)发生时间的相关因素。方法:测定CID患者的菌群分布,记录并分析年龄、性别、体质状况评分、肿瘤类型、临床分期、不同化疗方案、腹泻发生时间、腹泻程度等临床资料。结果:CID发生率为6.33%。CID患者有76.47%发生菌群失调,68例CID患者男43例,女25例;平均年龄53.93岁。PS评分:0分9例,1分7例,2分24例,3分25例,4分3例。肿瘤类型:结肠癌21例,胃癌18例,食道-贲门癌13例,肝癌4例,胰腺癌3例,十二指肠癌2例,胆囊癌2例,直肠癌5例。腹泻发生时间最短0d,最长62d,平均10.13d。化疗方案:FOLFIRI方案20例,FORFOX方案9例,DLF方案4例,TDLF方案5例,HDLF方案16例,NDLF方案9例。GDLF方案5例。腹泻发生程度:Ⅰ度1例,Ⅱ度6例,Ⅲ度60例,Ⅳ度1例。结论:CID患者绝大部分发生菌群失调,不同体质状况评分、不同化疗方案影响CID发生时间,而年龄、性别、肿瘤类型、临床分期、不影响CID发生时间。
Objective：To discuss the retated factors of chemotherapy- induced diarrhea during combination Chemotherapy based on 5 - FU for digestive tract carcinoma. Methods： In 68 CID patients, the flora disturbance was determined, the clinical data including age, sex, PS score, tumor type, clinical stage, different chemotherapy regimens,occuring time and degree of diarrhea, were recorded and analysed. Results：The incidence of CID was 6.33 %. 76.47 % of these patients had flora imbalance. Among 68 CID patients, 43 patients were males and 25 females,the average age was 53.93 years old ,PS score was o in 9 patients,1 in 7 ones,2 in 24 ones,3 in 25 ones and 4 in 3 ones. There were 21 patients with colonic tumor, 18 with gastric tumor, 13 with esophageal - cardia tumor,4 with liver tumor,3 with pancreatic tumor,2 with duodenal tumor,2 with gallbladder tumor and 5 with rectal tumor. The average duration of diarrhea was 10.13 days （range,o to 62 days）. 20 patients received FOLFIRI regimen, 9 received FORFOX regimen, 4 received DLF regimen, 5 received TDLF regimen, 16 received HDLF regimen,9 received NDLF regimen and 5 received GDLF regimen. The degree of dirrhea was Ⅰ in 1 patient, Ⅱ in 6 patients, Ⅲ in 60 patients and Ⅳ in 1 patient. Conclusion：Most CID patients have flora imbalance. PS score and chemotherapy regimens are related with age, sex and tumor type. Clinical stage are not velated to CID
出处
《内蒙古医学杂志》
2005年第11期998-1000,共3页
Inner Mongolia Medical Journal
关键词
化疗相关性腹泻
相关因素
Chemotherapy - induced diarrhea
Related factor
