摘要
目的:测定盐酸去氢骆驼蓬碱的血浆蛋白结合率。方法:采用超滤法和高效液相色谱法对盐酸去氢骆驼蓬碱的血浆蛋白结合率进行测定。结果:盐酸去氢骆驼蓬碱与小牛血清白蛋白、人血清白蛋白和正常人血浆的蛋白结合率分别为(74.6±9.8)%、(69.1±8.7)%、(87.1±5.3)%。结论:盐酸去氢骆驼蓬碱与血浆蛋白具有中等强度的结合。
OBJECTIVE To study the plasma protein binding rate of harmine hydrochloride. METHODS The ultrafiltration was employed to determine the plasma protein binding rate of harmine hydrochloride. The plasma concentrations of harmine hydrochloride were measured by RP-HPLC. RESULTS The plasma protein binding rate of harmine hydrochloride with BSA, HSA and normal human plasma were （74.6±9.8）%,（69.1 ±8.7）% and （87.1±5.3）%, respectively. CONCLUSION The binding rate of harmine hydrochloride with plasma protein is middling strength.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2005年第2期99-101,共3页
Chinese Journal of Hospital Pharmacy
基金
国家科技攻关资助项目(编号:2001BA754C)
关键词
盐酸去氢骆驼蓬碱
血浆蛋白结合率
超滤法
harmine hydrochloride
plasma protein binding rate
ultrafiltration
