摘要
目的观察帕罗西汀合并小剂量奥氮平治疗抑郁症的临床疗效。方法70例抑郁症患者随机分成帕罗西汀组(单用组)和帕罗西汀合用奥氮平组(合用组)。共观察8周,于治疗前,治疗后1、2、4、6、8周末采用汉密顿抑郁量表(HAMD),副反应量表(TESS)评定疗效及副反应,并随访1年,观察其1年内的复发率。结果治疗第8周末,帕罗西汀合用小剂量奥氮平组疗效显著,合用组与单用组的显效率分别为87.51%和66.66%,差异有显著性(χ2=9.46,P<0.05);合用组在1周末起效,单用组在2周末起效;治疗后1、2、4周HAMD评分差异有显著性(χ2=5.36,P<0.05);两组的HAMD因子分在焦虑/躯体化和睡眠障碍方面差异有显著性;TESS评分及1年内复发率无明显差异(χ2=1.96,P>0.05)。结论帕罗西汀合用小剂量奥氮平治疗抑郁症起效快,克服了抗抑郁药本身起效慢的特点,可提高疗效,并能迅速改善睡眠障碍和焦虑/躯体化症状,对复发率无明显影响。
Objective： To study the clinical effect of paroxetine with small-dose olanzapine in the treatment of depression. Methods： 70 hospitalized patients or outpatients who met CCMD-3 criteria of depression were randomly divided into research （paroxetine and olanzapine） group and control （paroxetine） group for the treatment of 8 weeks. The efficacy and side effects were evaluated with HAMD and TESS. The rates of relapse in one year were observed by following up the patients. Results： The treatment of paroxetine with olanzapine was effective and the tolerance was better after 8-week treatment. There were significant differences in recovery rate, HAMD of first week, second week, forth week and HAMD gene score of symptom of body discomfort, sleep disorder and orexis after treatment between two groups. But there was no difference in TESS and the rate of relapse in one year between two groups. Conclusion： Paroxetine with small-dose olanzapine could improve the efficacy compared with paroxetine in treating depression, and could improve sleep disorder、orexis and the feeling of body discomfort. Also olanzapine had no distinct effect on relapse.
出处
《上海精神医学》
2005年第5期268-270,共3页
Shanghai Archives of Psychiatry
