期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

白血病抑制因子在周围神经损伤修复中的应用 被引量：3

在线阅读 下载PDF
导出
摘要 神经营养因子在周围神经损伤中的应用,是当前的一个研究热点。白血病抑制因子(LIF)是一种对感觉、运动和自主神经元都敏感的神经营养因子,周围神经损伤后其在损伤处的表达上调且逆行运输至神经元胞体的量增加,通过与相应受体结合后,起着维持损伤后神经元的存活;促进神经轴突的生长;参与神经损伤后的炎性反应;调节神经元基因和多种神经肽的表达;促进其它神经营养因子的分泌等生物效应,在周围神经修复再生过程的多个方面中起着重要的作用。
作者 刘峰 袁贤瑞
机构地区 中南大学湘雅医院神经外科
出处 《国际神经病学神经外科学杂志》 2005年第5期442-444,共3页 Journal of International Neurology and Neurosurgery
关键词 血病抑制因子(LIF) 周围神经 神经再生 白血病抑制因子(LIF) 周围神经损伤 损伤修复 神经营养因子 神经元胞体 周围神经修复 逆行运输
分类号 R651.3 [医药卫生—外科学]
  • 相关文献

参考文献15

  • 1Scherer SS, Xu Y, Roling D. et al. Axons modulate the expression of leukemia inhibitory factor by Schwann cells. Soc Neurosci.Abstr. 1993, 19( 1 ) :246.
  • 2Matsuoka I, Nakane A, Kurihara K. Induction of LIF-mRNA by TGF-beta 1 in Schwann cells. Brain Res. 1997,776 ( 1-2 ) :170-180.
  • 3Dowsing BJ, Morrison WA, Nicola NA, et al. Leukemia inhibitory factor is an autocrine survival factor for Schwann cells. J Neurochem . 1999. 73 (1) :96-104.
  • 4Schweizer U, Gunnersen J, Kareh C. et al. Conditional gene ablation of Star3 reveals differential signaling requirements for survival of motoneurons during development and after nerve injury in the adult. The Journal of Cell Biology, 2002,156 ( 2 ) : 287-298.
  • 5Kato R, Kiryu-Seo S, Kiyama H. Damage-induced neuronal endopeptidase (DINE/ECEL) expression is regulated by leukemia inhibitory factor and deprivation of nerve growth factor in rat sensory ganglia after nerve injury. J Neurosci, 2002, 22 ( 21 ) : 9410-9418.
  • 6Cheema SS, Richards LJ, Murphy M. et al. Leukaemia inhibitory factor rescues motoneurones from axotomy-induced cell death.Neuroreport. 1994,5 ( 8 ) :989-992.
  • 7Cheema SS, Richards L, Murphy M. et al. Leukemia inhibitory factor prevents the death of axotomised sensory neurons in the dorsal root ganglia of the neonatal rat. J Neurosci Res. 1994,37(2) :213-218.
  • 8Cafferty WB, Gardiner NJ, Gavazzi I. et al. Leukemia inhibitory factor determines the growth status of injured adult sensory neurons. J Neurosci. 2001 ,21(18) :7161-7170.
  • 9Tham S, Dowsing B, Finkelstein D. et al. Leukemia inhibitory factor enhances the regeneration of transected rat sciatic nerve and the function of reinnervated muscle. J Neurosci Res. 1997,47(2) :208-215.
  • 10Tofaris GK, Patterson PH, Jessen KR. et al. Denervated Schwann cells attract macrophages by secretion of leukemia inhibitory factor (LIF) and monocyte chemoattractant protein-1 in a process regulated by interleukin-6 and LIF. J Neurosci. 2002,22(15) :6696-6703.

同被引文献31

  • 1马涛,肖雪,吕琦,王泽华,马岚.人白血病抑制因子真核表达载体的构建及在哺乳动物细胞中的表达[J].云南大学学报（自然科学版）,2006,28(S1):387-392. 被引量：1
  • 2HILTON D J. LIF:lots of interesting fimcfions [J]. Trends in Biochemical Sciences, 1992,17:72.
  • 3METCALF D. The unsolved enigmas of leukemia inhibitory factor [J]. Stem Cells,2003,21:5.
  • 4Sun Y, Zigrnond RE. Leukaemia inhibitory factor induced in the sciatic nerve after axotomy is involved in the induction of galanin in sensory neurons[J].Eur J Neurosci,1996,8 (10):221.
  • 5Auemhammer CJ, Chesnokova V, Melmed S. Leukemia inhibitory factor modulates interleukin-1 -induced activation of the hypothalamo-pitu-itary-adrenal ads[J]. Endocrinology, 1998,139(5) :2201.
  • 6Murphy M, Reid K, Brown MA, Bartlett PF. Involvement of leukemia inhibitory factor and nerve growth factor in the development of dorsal root ganglion neurons [ J ]. Development, 1993,117:1173.
  • 7Cheema SS, Richards L, Murphy M, Bartlett PF. Leukemia inhibitory factor preventsthe death of axotomised sensory neurom in the dorsal root ganglia of the neonatal rat[J] .JNeurosci Res,1994,37:213.
  • 8Cheema SS, RichardsLJ, MurphyM, Bartlett PF. Leukemia inhibilory factor rescues motoneurones fxom axotomy-induced cell death[J]. Neurore-port, 1994,5:989.
  • 9Gadient RA, Lein P, Higgim D, Patterson PH. Effect of leukemia inhibitory factor (LIF) on the morphology and survival of cultured hippocampal neurons and glial cells[J]. Brain Res, 1998,798 (1 - 2) : 140.
  • 10Banner LR,Pattermn PH. Major changes in the expression of the mRNAs for cholinergic differentiation factor/leukemia inhibitory factor and its re- ceptor after injury to adult peripheral nerves and ganglia[ J ]. Proc Nail Acad Sci USA, 1994,91(15) :7109.

引证文献3

二级引证文献7

国际神经病学神经外科学杂志
2005年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部