摘要
研制了盐酸拉贝洛尔缓释片，研究了其人体内药物动力学。缓释片体外可维持释药１２ｈ，释药行为可用Ｈｉｇｕｃｈｉ方程来描述，溶出速度常数为４．２６ｍｉｎ￣（－１／２）；其体内药动学过程符合一级吸收单室模型，药动学参数为：Ｋａ＝１．７１ｈ￣（－１），Ｋ＝０．１２４８ｈ￣（－１），Ｃｍａｘ＝６１．９３ｎｇ／ｍｌ，Ｔｍａｘ＝１．８９ｈ，ＡＵＣ￣（０→∞）＝６０３．９ｎｇ·ｈ／ｍｌ。
Sustained release tablets(SRT)of labetalol and the human pharmacokinetics were studied. The results indicated that the SRT was able to produce a sustained release of the drug for 12 h.The drug release pattern in vitrO of the SRT was best described by Higuchi equation with a release constant being 4.26 min and the plasma drug level data best fit the one compartment open model with first order absorption. The parmacokinetic parameters Kα,K,C(max),T(max) and AUC of labetalol HCl were 1.17 h-1,0.1248 h-1, 61.93 ng/ml,1.89 h and 603.9 ng·h/ml respectively.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1996年第1期13-15,共3页
Journal of China Pharmaceutical University
关键词
盐酸拉贝洛尔
缓释片
药物动力学
Labetalol hydrochloride
Sustained release tablets
Pharmacokinetics
