摘要
目的:检测喉鳞状细胞癌(LSCC)中环氧化酶2(COX2)、兔抗人Ⅷ因子(FⅧ)的表达,探讨LSCC中COX2的表达情况与微血管密度(MVD)的关系。方法:利用免疫组织化学SABC法检测42例LSCC及其癌旁正常组织中COX2、FⅧ的表达,分析其与LSCC的临床病理、淋巴结转移、MVD等的关系。结果:LSCC组织中COX2阳性率为71.4%,癌旁正常组织中COX2的阳性率为19.1%,肿瘤组织中COX2的表达明显高于癌旁正常组织,差异有统计学意义(P<0.05);COX2在LSCC中的表达与患者的性别、年龄、病变原发部位、分化程度和T分期无关(均P>0.05);与病理分期、颈淋巴结转移和MVD密切相关。结论:COX2在LSCC中的高表达对肿瘤的发生、发展及淋巴结转移起促进作用,COX2可能是促进肿瘤血管形成的主要因子。
Objective：To investigate the expression of cyclooxygenase-2 in laryngeal squamous cell carcinoma and the correlation with tumor angiogenesis. Method： The COX-2 and FⅧ of 42 cases of laryngeal squamous cell carcinoma were detected by immunohistochemical SABC method,and the correlation between the expression rates, clinical significance and microvessel density（MVD） was analyzed. Result： The positive rate of COX-2 in laryngeal squamous cell carcinoma tissues and adjacent normal tissues were 71. 43% and 19. 05% respectively. The expression of COX-2 were not associated with age, sex, tumor site and T stage. The tumors of grade Ⅲ-Ⅳ showed a higher COX-2 expression than tumors of grade Ⅰ-Ⅱ did and the expression of COX-2 in the cervical lymph node metastasis group was higher than that in the non metastasis group. The expression of COX-2 was closely associated with microvessel density（MVD） of laryngeal squamous cell carcinoma. Conclusion：The expression of COX-2 may play a crucial role in the carcinogenesis and development of laryngeal squamous cell carcinoma and cervical lymph node metastasis in patients with laryngeal squamous cell carcinoma. COX-2 may be a important factor in tumor angiogenesis.
出处
《临床耳鼻咽喉科杂志》
CAS
CSCD
北大核心
2005年第21期967-970,共4页
Journal of Clinical Otorhinolaryngology
关键词
喉肿瘤
癌
鳞状细胞
环氧化酶
肿瘤血管形成
Laryngeal neoplasms
Carcinoma, squmous cell, Cyclooxygenase, Tumor angiogenesis
