摘要
目的观察尿毒症维持性血液透析治疗患者应用重组促红细胞生成素(rHuEPO)抗贫血治疗前、后患者认知功能的变化。方法对31例尿毒症维持性血液透析治疗患者在rHuEPO治疗前、后进行血红蛋白值、MMSE评分及P300认知电位检查,并与28例正常对照组比较。结果尿毒症维持性血液透析治疗患者在予rHuEPO治疗后血红蛋白值提高、MMSE评分提高、P300潜伏期缩短、波幅增大较rHuEPO治疗前有显著差异(P<0.01)。结论rHuEPO抗贫血治疗能改善尿毒症维持性血液透析治疗患者贫血状况,并能改善尿毒症患者认知功能。
Objective Evaluate the effects of recombinant human erythropoietin（rHuEPO） treatment in uraemic haemodialysis patients. Methods This study was performed in 31 patients with chronic uraemia, and 28 health subjects. All the subjects were investigated in terms of hemoglobin,the Mini-mental state examination（MMSE）and P300 cognitive potential obtained from auditory stimuli with oddball paradigm. The patients undergoing haemodialysis were evaluated before and after 4 months treatment with rHuEPO. Results After treatment with rHuEPO, patients showed hemoglobin and the MMSE score were greater,P300 latency decreased and amplitude increased compared with before treatment with rHuEPO（P〈0.01）. Conclusion RHuEPO therapy have a progressive effect on improving hemoglobin and cognitive function in uraemic haemodialysis patients.
出处
《江西医药》
CAS
2005年第9期507-509,共3页
Jiangxi Medical Journal
