摘要
目的观察三七总皂苷对肝纤维化小鼠血清中TNFα及IL-6活性的影响。方法用CCl4复制小鼠中毒性肝纤维化模型,ELISA法测定血清TNFα和IL-6,并行肝脏病理检测。结果三七总皂苷能减轻肝纤维化程度,降低肝纤维化小鼠血清中TNFα和IL-6的水平。结论三七总皂苷具有抗肝纤维化作用,其机理可能与降低血清中TNFα和IL-6的水平有关。
Objective： To observe effects of Panax notoginseng saponins（PNS） on TNFα and IL-6 of serum in mice with liver fibrosis. Methods：The liver fibrosis model induced by CCl4 was established in mice and they were treatment with PNS. Serum level of TNFa and IL-6 were determined and tissue pathology wa.s observed. Results： There are significant decrease the level of TNFα and IL-6 in serum with PNS treatment, the liver fibrosis was improved. Conclusion： PNS has reversal effects on hepatic fibrosis mice, it may be correlated with drop serum level of TNFα and IL-6.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2005年第4期31-33,共3页
Pharmacology and Clinics of Chinese Materia Medica
