摘要
目的探讨进展性脑梗死相关危险因素.方法 2002-10～2003-11对浙江省温州市第二人民医院急性脑梗死(ACI)152例入院时记录性别、年龄、血压、病史(包括糖尿病、高血压、高脂血症、脑梗死史、高尿酸血症、吸烟史),并予血常规、凝血功能、血糖、肾功能、血脂、载脂蛋白,心肌酶、D-二聚体、纤维蛋白降解产物、C反应蛋白、肌钙蛋白I,抗凝血酶Ⅲ、头颅MRI(或CT)、颈动脉彩超检查.累计稳定性脑梗死98例和进展性脑梗死54例,对上述指标进行统计学检验.结果 46项指标中C反应蛋白(CRP)、白细胞(WBC)、载脂蛋白B(apoB)、血糖(GLU)、乳酸脱氢酶(LDH)、肌酸激酶同工酶MB(CPK-MB)、а-羟丁酸脱氢酶(а-HBDH)和舒张压(DBP)差异有统计学意义,入院时CRP、WBC、apoB、GLU、LDH、CPK-MB、а-HBDH升高和 DBP下降易致脑梗死进展.结论入院时CRP、WBC、apoB、GLU、LDH、CPK-MB、а-HBDH升高和 DBP下降可作为急性脑梗死进展的预测指标.
Objective To analyse correlated risk factors of evolving cerebral infarction （ECI）. Methods The follow data was recorded in the acute cerebral infarction （ACI） cases when they were admitted ： sex, age, systolic blood pressure （SBP）, diastolic blood pressure （DBP）, history, of disease （diabetes mellitus, hypertension, hyperlipidaemia, cerebral infarction, hyperuricemia or smoking）. The following examinations or determinations were done, including： white blood cell count （WBC） , platelet count （PLT） , blood gluconate （GLU） , PT-INR, fibrinogen （FG）, TT - INR, APTT - INR, C - reactive protein （ CRP）, D - dimer （ D -D）, products of fibrin degradation （ FDP）, anti - thrombin Ⅲ （ATⅢ）, apolipoprotein A （apoA）, apolipoprotein B （apoB） , blood urea nitrogen （BUN） , creatinine （CR）, triglyceride （TG）, high density lipoprotein （HDL）, low density lipoprotein （LDL）, very low density lipoprotein （VLDL）, GOT, lactate dehydrogenase （LDH）, creatine phosphokinase （CPK）, MB isoforms of creatine phosphokinase （CPK- MB）, α hydroxybutyrate dehydrogenase （α- HBDH）, troponin I （TnI）, cerebral CT or MRI and carotid ultrasonography. The patients were divided into two groups, ECI and completed cerebral infarction （CCI） , according whether neurons function scale deteriorated. When cases of both groups exceeded 50, We took statistic test by SPSS10. 0 statistic software. Results 8 of the above 46 markers had significant defference between the two groups, including CRP, WBC, apoB, GLU, LDH, CPK-MB, a- HBDH and DBP. ECI was more common in patients who had lower DBP or higher CRP, WBC, apoB, GLU, LDH, CPK - MB, a - HBDH when they were admitted. Conclusion The increase of CRP, WBC, apoB, GLU, LDH, CPK - MB, a- HBDH or decrease of DBP when patients are admitted can be predictive markers of ECI.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2005年第10期895-896,共2页
Chinese Journal of Practical Internal Medicine
基金
温州市卫生局基金资助项目(2002012)
关键词
脑梗死
进展
危险因素
Cerebral infarction Evolution Risk factors
