摘要
目的:研究乳腺癌组织中尿激酶型纤溶酶原激活物(urokinase-type plas-minogen activator,uPA)的表达与肿瘤浸润转移的关系,揭示乳腺癌的浸润转移机制。方法:应用SP免疫组化方法检测102例乳腺癌组织和30例乳腺非癌组织中uPA的表达情况及其与临床病理参数的关系。结果:在102例乳腺癌组织中,uPA的阳性表达率为70.6%(72/102),与良性对照组比较差异有统计学意义,χ2=16.073 5,P=0.005;乳腺癌组织中uPA的阳性表达与腋窝淋巴结转移和临床TNM分期有关;uPA的阳性表达与年龄、肿瘤大小、病理分级无关。结论:乳腺癌uPA的阳性表达与肿瘤的浸润转移密切相关,uPA通过对基底膜和细胞外基质的降解,而促使癌细胞的浸润和转移。因此,检测uPA有助于判断乳腺癌的生物学行为,并提示可能是评估乳腺癌预后的一项有价值的指标。
OBJECTIVE： To investigate the expression of urokinasetype plasminogen activator （uPA） in breast carcinoma tissue, to find out the relationship between tumor invasion and metastasis, and to disclose the mechanism of the tumor invasion and metastasis of breast carcinoma. METHODS： Tissues were obtained from 102 patients with breast carcinoma and 30 ones without breast carcinoma. The expression of uPA was examined by the immunohistochemical technique （streptavidin-peroxidase conjugate method, SP） ,and the results were analysed and correlated with clinicopathological tumor parameters. RESULTS： The positive incidence of uPA expression in 102 cases of breast carcinoma was 70. 6% （72/102）, which differentiated significantly that of the control group （X^2 = 16. 0735,P=0. 005）. The expression of uPA were related to axillary lymph node metastasis and TNM stage, and the expressions of uPA were not related to age, tumor size and the histologic grade. CONCLUSIONS： uPA expression is closely related to the tumor invasion and metastasis of breast carcinoma, uPA is involved in the processes leading to the degradation reaction of basement membrane and extracellular matrix, which can damage basement membrane and extracellular matrix leading to the tumor invasion and metastasis. Detection of this index may be helpful for judging biologic behavior of breast carcinoma,which suggests that it is a useful prognostic indicator for breast carcinoma.
出处
《肿瘤防治杂志》
CAS
2005年第16期1244-1247,共4页
China Journal of Cancer Prevention and Treatment
基金
福州市科委基金(2001350102000709)
