摘要
目的综述以纳米颗粒作为基因载体进行基因治疗的发展概况。方法依据国内外刊物公开发表的文献,对有关以纳米颗粒作为基因递送载体进行基因治疗的研究进行分类、归纳与整理。结果纳米颗粒转运系统能够保护被转运的基因,有较高的转染效率,具有良好的靶向性,并且提高了药物的生物利用度,显示出一定的缓控释作用。结论纳米颗粒作为基因递送载体具有广阔的发展前景。
Objective To review the development of genic therapy with the nanoparticle as carrier. Methods Based on the publicly literature, the research work on genic therapy, which use nanoparticles as carrier, was classified and summarized. Results Nanoparticle carrier system can protect the genes, have a high carrying efficiency and a well targeting property, it also can improve the bioavailability, sustained and controlled release. Conclusions Using nanoparticles as genic carrier have a wide developmental foreground.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2005年第5期395-400,共6页
Journal of Shenyang Pharmaceutical University
