摘要
目的:探讨周围型肺癌16层螺旋CT征象与肿瘤内微血管密度的关系。为将16层螺旋CT作为一种评价肿瘤血管生成的无刨性检查手段应用于临床提供理论依据。方法:收集48例经手术及病理证实的周围型肺癌(鳞癌27例,腺癌21例)。术前行16层螺旋CT扫描,用S-P免疫组化法检测病理标本的微血管密度。结果:周围型肺癌中腺癌微血管密度(microvesseldensity,MVD)明显高于鳞癌,分别为61.57±10.29和52.46±11.32(P<0.05)。肺癌MVD值与16层螺旋CT影像上肿瘤直径、分叶征、血管集束征、胸膜凹陷征及纵隔淋巴结转移均有密切关系(P<0.05)。结论:周围型肺癌16层螺旋CT征象与其微血管密度值有密切关系。可用于预测肺癌的组织学类型和评价其恶性程度。
Objective： To investigate the relationship between the 16-slice spiral CT appearances and the microvessel density（MVD） in patients with peripheral lung cancer, and to popularize 16-slice spiral CT as non-invasive method to estimate the tumor angiogenesis. Methotis： Forty-eight patients with peripheral lung cancer proved by surgery and pathology were underwent 16-slice spiral CT scan before operation, including 27 squamous cell carcinoma and 21 adenocarcinoma. The MVD was measured in resected tumor specimens with immunohistoehemical method of SP. Results： The MVD value of adenocarcinoma was significantly higher than that of squamous cell carcinoma（61.57±10. 29 versus 52. 46±11.32, P〈0. 05）. There were significant relationships between the MVD value and diameter of tumor, lobulation sign, vessel convergence sign, pleural retraction sign and lymph node metastasis （P〈0. 05）. Conclusion： The 16-slice spiral CT appearances of peripheral lung cancer are closely related to their MVD values, which might be an indicator to identify the histological classification and to predict the malignant degree of tumor.
出处
《中国临床医学》
北大核心
2005年第4期692-694,共3页
Chinese Journal of Clinical Medicine
