摘要
目的:观察左旋卡尼汀联合重组人促红细胞生成素(rhEPO)治疗肾性贫血的临床疗效。方法:54例维持血液透析的肾性贫血患者随机分为三组:A组18例,透析后静脉注射左旋卡尼汀1g;B组18例,采用rhEPO3000IU皮下注射,23次/周;C组18例,透析后静脉应用左旋卡尼汀1g,同时应用rhEPO3000IU皮下注射23次/周。观察三组患者治疗前及治疗4、8、12周的血浆白蛋白、血红蛋白、红细胞体积的情况。结果:随着治疗的进行,A组血浆白蛋白显著升高,与B组比较,差异有显著性(P<0.05);C组血浆白蛋白、血红蛋白上升最明显,与A、B组比较差异有显著性(P<0.05);C组rhEPO用量明显低于B组。结论:左旋卡尼汀可改善维持血液透析患者的状态,提高rhEPO的疗效,减少rhEPO的用量。
Objective： To evaluate the effect of L-carnitine plus rhEPO on nephritic anemia, Methods, Fifty-four maintenance hemodialysis patients with anemia were randomly divided into 3 even groups. Group A, B and C received intravenous injection of 1.0 g of Lcarnitine after each hemodialysis, subcutaneous injection of 3000IU of rhEPO 2 to 3 times a week, and both for 12 weeks, respectively, Serum albumin, hemoglobin （Hb） and hematocrit （Hct） levels were detected before and after treatment. Results,, Compared with Group B, serum albumin level increased significantly in Group A and C （P〈0.05）, especially in Group C. The dosage of rhEPO in Group C was significantly lower than that in Group B, Conclusion; L-carnitine treatment can improve rhEPO efficacy and decrease its dosage in hemodialysis patients with renal anemia.
出处
《广东医学院学报》
2005年第5期505-506,共2页
Journal of Guangdong Medical College
