摘要
目的研究探讨COX-2抑制剂尼美舒利对CCL4诱导的肝纤维化大鼠胃黏膜损伤愈合的影响。方法取雄性SD大鼠20只,按体重随机分为两组,模型组(n=10):40%CCL4油0.3mL/100g体重灌胃,每周2次;尼美舒利治疗组(n=10):40%CCL4油0.3mL/100g体重灌胃,每周2次,同时给予尼美舒利6mg/(kg·d),每天1次,于第8周取材,光镜下观察肝脏组织学改变,进行胃黏膜损伤和炎症指数评价。结果尼美舒利治疗组大鼠肝组织纤维化程度减轻,纤维间隔较为细小,且胃黏膜炎症评分明显低于模型组(P<0.01),损伤评分亦低于模型组(P<0.05)。结论尼美舒利能够在一定程度上减轻肝纤维化大鼠的肝纤维化程度,对其损伤的胃黏膜有保护作用,促进愈合。
[Objective] Cyclooxygenase（COX）,the key enxyne for synthesis of prostaglandins （PGs）, exists in two isoforms （COX-1 and COX-2）. Conventional nonsteroidal anti-inflammtory drugs （NSAIDs） are limited in application as it inhibitor both COX-1 and COX-2 activities simultaneously and induce serious gastrointestinal side effects. But, specific COX-2 inhibitors are expected to become a new type of NSAIDs without much gastric side effects because it can inhibit COX-2 activity, only. The aim of this study was to investigate the effects of cyclooxygenase-2 inhibitors Nimesulide on the healing of gastric mucosal damage in fribrotic rats induced by CCIA. [Methods] 40 male wistar rats were randomly divided into 2 groups in term of weight. Model group （n =10）：the rats were treated with 40% CCIA 0.3 mL/100 g body weight by daily gastrogavage two times a week. Nimesulide group（n =10）： the rats were treated with 40% CCIA 0.3 mL/100 g body weight by daily gastrogavage two times a week. Nimesulide was given 6 mg/（kg, d） only one time a week at the same time. After 8 weeks, liver morphological examination was based on microscopy. Meanwhile, the score of gastric mucosal impairment and inflammtion were assessed. [Results] Mean fibrosis was reduced in Nimesulde treatment group, and there was a marked decline of both inflammatory score （P 〈 0.01 ） and injured score （P 〈0.05） in it, compared to those of the model group. [Conclusions] Nimesulide can not only alleviate fibrosis on fibrotic rats to some extent, but also offer protective effects on injured gastric mucosa and accelerate their healing.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2005年第16期2443-2446,共4页
China Journal of Modern Medicine
关键词
环氧合酶-2
胃黏膜损伤
非甾体类抗炎药
肝纤维化
尼美舒利
cyclooxygenase-2
gastric mucosal injuries
nonsteroidal anti-inflammtory drugs
hepatic fibrogenesis
Nimesulide
