摘要
目的探讨肺炎衣原体(CP)及幽门螺杆菌(HP)抗体、炎症标记物C反应蛋白(CRP)与冠心病(CHD)的相互关系。方法采用酶联免疫法测定50例冠心病患者、33例冠脉造影正常非冠心病组患者和44例正常对照者血清CPIgG和IgM及HPIgG和IgM,同时应用免疫比浊法测定上述人群血清超敏CRP。结果冠心病组与非冠心病组和正常对照组CPIgG、HPIgG抗体阳性率比较均有显著性差异(P<0.01);冠心病组血清CRP含量较两个对照组明显升高(P<0.01);CPIgG和HPIgG同时阳性较CPIgG阳性或这两种病原体IgG阴性CHD的发病率明显升高(P<0.01),且CRP值亦随这两种病原体抗体阳性而增高;CPIgG较HPIgG阳性率高(P<0.01)。但此两种病原体的IgG阳性存在正相关(r=0.467)。结论CP、HP感染及超敏CRP含量与CHD的发生密切相关。
Objective To investigate the relationship between infection of Chlamydia pneumoniae（CP） and Helicobacter pylori（HP） and high-sensitivity C-reactive protein （hs-CRP）with coronary heart disease（CHD）. Methods Paired sera from 50 CHD patients and 41 non-（HI） patients and it normal healthy subjects were studied to detect IgG,IgM antiboby against CP and HP with enzyme linked immunosorbent assay. The serum levels of hs-CRPin three kinds men were measured by immunoturbidimetry . Results There were statistical differences between serum CP IgG or 11P IgG in peo ple of CHD and non-CHD, normal healthy subjects（P〈0. 01,P〈0. 01）. Mean hs-CRP value was significantly higher in patients with CHD ,compared with another groups（ P〈0. 01, P〈0. 01）. Conclusion There exists a close relationship between CP,HP infection,hs-CRP and CHD.
出处
《国外医学（临床生物化学与检验学分册）》
2005年第8期484-487,共4页
Foreign Medical Sciences(section of Clinical Biochemistry and Laboratory Medicine
