摘要
目的观察应用阿托伐他汀治疗前、后心力衰竭患者心功能及一氧化氮(NO)、降钙素基因相关肽(CGRP)和内皮素(ET)水平的变化,探讨阿托伐他汀在心力衰竭治疗中的作用。方法将60例CHF患者随机分为对照组和阿托伐他汀组,对照组30例给予常规抗心力衰竭药物治疗,阿托伐他汀组30例在此基础上给予阿托伐他汀20mg/d。分别于治疗前、治疗6个月后测定左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、ET、CGRP、NO的含量。结果治疗后LVEF明显增加、LVEDD缩小,NO、CGRP水平升高,ET水平下降(P<0.01)。阿托伐他汀组改善更为显著,与对照组相比差异有统计学意义(P<0.05)。结论阿托伐他汀可改善CHF患者的心功能及NO、CGRP与ET的失衡。
Objective To study the effect of atorvastatin on cardiovascular function and the levels of plasma nitric oxide (NO) , calcitonin gene-related peptide (CGRP) and endothelin (ET) in patients with chronic heart failure (CHF) .Methods Sixty cases of CHF were randomly divided into two groups,i.e.trial group (n=30) which was given usual treatment according to the guide-lines of CHF treatment and control group (n=30) which received 20 mg of atorvastatin daily.Before and after 6 months’treatment,two groups were measured the levels of NO,CGRP,ET,LVEF and LVEDD.Results After treatment,LVEF was obviously increased while LVEDD was decreased,and the levels of NO and CGRP were obviously higher than that before treatment while ET was lower (P<0.01) .More significant improvements could be seen in trial (atorvastatin) group (P<0.05) .Conclusion Atorvastatin obviously improves cardiovascular function and metabolic imbalance of NO,CGRP and ET in patients with CHF.
出处
《临床军医杂志》
CAS
2010年第4期537-538,共2页
Clinical Journal of Medical Officers
关键词
阿托伐他汀
心力衰竭
心功能
血管活性物质
atorvastatin
chronic heat failure
cardiovascular function
vascular active substance
