摘要
采用体内试验和体外试验方法，观察氯化镉对小鼠免疫功能的影响。免疫后不同时间，给小鼠一次灌胃３０ｍｇ／ｋｇＣｄＣｌ_２，未见对免疫功能产生明显影响。反复多次灌胃染毒１４天，在０．３ｍｇ／ｋｓ／ｄ组可见明显抑制小鼠脾淋巴细胞ＩｇＭ－ｐＦＣ，抑制率为４２．１％。体外试验表明，１２．５μｍｏｌ／ＬＣｄＣｌ_２与淋巴细胞作用４８ｈ，２５μｍｏｌ／ＬＣｄＣｌ_２作用７２ｈ，对淋巴细胞增殖反应抑制率分别为３８．３％和７７．８％，以上结果表明氟化钢具有明显的免疫毒性。
n this paper, animal experiments both in vivo and in vitro were used to evaluate the effect in immune functions of mice exposed, to cadmium chloried , CdCl_2 given by single dose of 30mg/kg to mice at various times (D0,D1,D2) after immunization did'nt show any effect on immune function. But mice were exposed to CdCl2 by repeated administration at dosage of 0. 3mg/kg/d, the number of IgM-PFC was markedly depressed to 42. 1%. In vitro experiment 12. Sμmol/L CdCl_2 were incubated with lymphocytes for 48hrs and 25.0μmol/L CdCl_2, for 72hrs,the lymphocyte proliferation was significantly suppressed to 38. 3% and 77. 8% respectively.The results showed the cadmimum chloride has obvious immunotoxicity.
出处
《中国环境科学》
EI
CAS
CSSCI
CSCD
北大核心
1995年第1期76-78,共3页
China Environmental Science
