摘要
从新疆藁本（ＣｏｎｉｓｅｌｉｎｕｍｖａｇｉｎａｔｕｍＴｈｅｌｌ）的根茎中分到七个化合物，根据理化常数和光谱解析，分别鉴定为ｃｏｎｉｓｅｌｉｎ（Ⅰ），（Ｅ）－３－ｍｅｔｈｏｘｙ－４，５－ｍｅｔｈｙｅｎｅｄｉｏｘｙｃｉｎｎａｍｉｃａｌｄｅｈｙｄｅ（Ⅱ），（Ｅ）－３－ｍｅｔｈｏｘｙ－４，５－ｍｅｔｈｙｌｅｎｅｄｉｏｘｙｃｉｎｎａｍｉｃａｌｃｏｈｏｌ（Ⅲ），（Ｅ）－３－ｍｅｔｈｏｘｙ－４，５－ｍｅｔｈｙｌｅｎｅｄｏｘｙｃｉｎｎａｍｉｃａｃｉｄ（Ⅳ），肉豆劳动蔻酸（ｍｙｒｉｓｔｉｃｉｃａｃｉｄ，Ｖ），阿魏酸（ｆｅｒｕｌｉｃａｃｉｄ，Ⅵ）和香草醛（ｖａｎｉｌｉｎ，Ⅶ）。其中Ⅰ为新化合物，其余均为首次从该植物中分到。经药理实验表明化合物Ⅱ～Ⅴ对四氯化碳引起的小鼠转氨酶升高有降低作用，对丙酸杆菌引起的小鼠免疫性肝损伤有保护作用。
Seven compounds were isolated from the alcoholic
extract of Comiselinum vaginatum Thell.On the basis of their chemical
properties and spectral data (MS. UV.IR. 1H AND 13CNMR)they were
identified as conioselin,)-3-methoxy-4,5-methylenedioxycinnamic
aldehyde(Ⅱ),(E)-3-methoxy -4,5-methylejnedioxycinnamic
alcohol(Ⅲ),(E)-3- methoxy- 4 ,5-methylenedioxy-cinnamic acid
(Ⅳ),myristicic acid (Ⅴ),ferulic acid (Ⅵ) and vanilin).Compound Ⅰ
is a new compound,compounds Ⅱ,Ⅲ,Ⅳ,Ⅴ,Ⅵ and Ⅶ were obtained fOr
the first time from the titleplant.
出处
《药学学报》
CAS
CSCD
北大核心
1995年第7期526-530,共5页
Acta Pharmaceutica Sinica
基金
国家自然科学基金
