摘要
以１千万个／ｍｌ足样根霉（Ｒｈｉｚｏｐｕｓｒｈｉｚｏｐｏｄｉｆｏｒｍｉｓ）孢囊孢子悬液前腔静脉接种２月龄仔猪，每头５ｍｌ，每日１次，连续３日，经７０ｄ观察，可导致猪体形成毛霉菌病的特征病变，并有２头仔猪死亡。病猪临床表现精神沉郁，消瘦，体温升高，腹泻及末稍血管充血、出血，白细胞总数及嗜中性白细胞成倍增加，Ｓ－ＧＯＴ和Ｓ－ＧＰＴ、ＡＫＰ活性升高，血清胆固醇值上升，全血ＧＳＨ－Ｐ＿ｘ活性降低。病理学变化为胃憩室形成干酪样变，结肠和直肠壁遍布溃疡和圆形小结节。镜检部分血管内血栓形成，有毛霉菌丝；胃憩室部干酪样坏死区见淋巴细胞、单核细胞、巨细胞、嗜酸性白细胞及嗜中性白细胞增生，并有少量毛霉菌丝。
month-old piglets were inoculated precaval vein with 5ml suspended liquidcontaining 107 Rhizopus rhizopodiforms sporangiospores per millitre once a day forthree days,The characteristic pathological changes of mucormycosis were caused inpiglets during 70 days,and two of piglets died.The clinical symptoms of the sickpiglets were vigour listlessness,emaciation,fever,diarrhea,peripheral blood vesselhemorrhage and congestion.The total WBC and neutrophils had doubled and redoubled.The activities of SGPT,SGOT and AKP increased, The value of cholesterol raised,Butthe activity of the whole blood GSH-P_x was decreased.The main pathological changeswere that caseous material was formed in diverticulum ventriculi and a large quantitiesof ulcers and round nodes were scattered on colons and recta.Histologically, thrombiformed and mucoraceous hyphae invaded into some of the blood vessels.There wasproliferation of lympliocytes,monocytes, macropliages, eosinophils and neutrophils anda small quantities of mucoraceous hyphae were seen in the caseous necrotic areas ofthe diverticulum ventriculi of stomach.
出处
《畜牧兽医学报》
CAS
CSCD
北大核心
1995年第5期462-467,共6页
ACTA VETERINARIA ET ZOOTECHNICA SINICA
基金
国家自然科学基金
关键词
足样根霉
仔猪
毛霉菌病
病理学
临床学
猪病
Rhizopus rhizopodiform,Piglet,Mucormycosis pathology,Clinicalmanifestation
