摘要
研究了苜蓿皂甙降胆固醇作用以及对实验大鼠单核巨噬细胞系统功能的影响。结果表明，与高胆固醇血症组比较，苜宿皂甙可以显著降低实验动物血清ＴＣ和ＬＤＬ－Ｃ（均为Ｐ＜０．０１）。碳粒廓清试验表明，苜蓿皂甙可使校正吞噬指数（α）显著增加（Ｐ＜０．０５），半量清除时间（ｔ）显著缩短（Ｐ＜０．０１）。本研究结果初步提示，苜蓿皂甙降血清胆固醇作用与其增强单核巨噬细胞系统功能有关，应用于家族性高胆固醇血症的治疗可能有效。
The effects of alfalfa saponins on serum cholesterol and receptor independent pathway of LDL catabolism of the experimental hypercholesterolemic rats were observed. The results were as follows: Serum total cholesterol was significantly decreased (P<0.01) and serum low density lipoprotein cholesterol was significantly decreased (p<0.01). Corrected phagocytic index (α) of moncytic macrophages were significantly increased (P<0.05) and clearing time of half content (t) was significantly shortend (P<0.01). These results showed that the hypocholesterolemic effects of alfalfa saponins were related with promoting the function of monocytic macrophages and alfalfa saponins might be promising in the treatment of familial hypercholesterolemia.
出处
《徐州医学院学报》
CAS
1995年第2期118-120,共3页
Acta Academiae Medicinae Xuzhou
基金
江苏省教育委员会自然科学基金资助
