摘要
作者测试了１１６名矽尘接触者和８９名对照者血中脂质过氧化作用指标［丙二醛（ＭＤＡ）、过氧化物歧化酶（ＳＯＤ）、谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）］和血清铜、锌含量。结果显示，ＭＤＡ、ＳＯＤ、ＧＳＨ－Ｐｘ矽尘组分别为（５．５３１±１．８７２）μｍｏｌ／Ｌ、（２３９６±４１３）μｍｏｌ／（ｍｉｎ·ｇ）、（３５．０６±８．９４）μｍｏｌ／（ｍｉｎ·ｇ），均显著高于对照组。血清铜、锌、铜／锌比值矽尘组分别为（２４．８０±６．５６）μｍｏｌ／Ｌ、（１３．１１±４．６６）μｍｏｌ／Ｌ、２．２１±０．８７，血清铜、铜／锌比值明显高于对照组，而血清锌两组无显著差异。各指标间相关分析表明，ＭＤＡ与Ｃｕ、ＭＤＡ与Ｃｕ／Ｚｎ；ＳＯＤ与Ｃｕ、ＳＯＤ与Ｃｕ／Ｚｎ以及Ｃｕ与Ｃｕ／Ｚｎ呈正相关。其他指标之间无相关关系。作者认为生物膜的脂质过氧化和铜代谢在ＳｉＯ２所致的肺纤维化的病理机制中起重要作用，是肺纤维化有意义的指标，对判断肺损伤可能具有一定的价值。
The lipidperoxidation and the serum copper and zine concentrations of 116 workers exposed to silica dust and 89 control workers were determined.The results showed that the contents of MDA SOD and GSHPx of the exposed group were( 5. 531±1. 872) μmol/L,(2396±413) μmol/(min·g) and(36. 06±8. 84) μmol/(min·g),respectively.Which are significantly higher than that of the control. (P<0. 01, P <0.05).The content of copper, zinc and the ratio of copper to zinc of the exposed group were 24. 80±6. 56 and 13.11±4. 66 and 2.21±0. 87, respectively.The conpper content and the ratio of copper to zinc of the exposed group are significantly higher than that of the control group. There was no statisticaly difference between these two groups for serum zinc concentration. There were positive correlations between MDA and copper,MDA and the ratio of the copper to zinc, between SOD and copper and SOD and the ratio of the copper to zinc. It is suggested that lipidperoxide and copper play an important role in the pathogenesis of lung fibrosis caused by SiO2.
出处
《卫生研究》
CAS
CSCD
北大核心
1995年第4期193-195,共3页
Journal of Hygiene Research
关键词
矽尘接触
血液
脂质过氧化作用
铜
锌
silica dust
lipidperoxidation
serum copper and zinc concentration
