摘要
本文报道了肿瘤型马立克氏病（ＭＤ）鸡血清、全血或组织中的总超氧化物歧化酶（Ｔ－ＳＯＤ）、锰超氧化物歧化酶（Ｍｎ－ＳＯＤ）、铜锌超氧化物歧化酶（ＣｕＺｎ－ＳＯＤ）、过氧化氢酶（ＣＡＴ）和谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活性以及血清两二醛（ＭＤＡ）含量。统计结果表明，与健康鸡相比，肿瘤型ＭＤ鸡血清中Ｔ－ＳＯＤ、Ｍｎ－ＳＯＤ与ＣｕＺｎ－ＳＯＤ活性以及红细胞中的ＣＡＴ活性均极显著降低（Ｐ＜０．０１）；肿瘤组织的Ｔ－ＳＯＤ活性极显著地低于正常组织（Ｐ＜０．０１）；与健康鸡相比，肿瘤型ＭＤ鸡血清中的ＭＤＡ水平极显著升高（Ｐ＜０．０１），而血液ＧＳＨ－Ｐｘ活性差异不显著（Ｐ＞０．０５）。作者初步认为，氧自由基介入了肿瘤型ＭＤ的发展过程。
Marek's disease (MD) caused by a herpesvirus is most common of the neoplastic didests of chickens.The activities of total superoxide dismutase (T-SOD),Mn-SOD, Cu Zn-SOD, catalase (CAT) and glutethione peroxidase(GSH-Px) and the level of malondialdehyde (MDA) in the serum, blood or tissues of 36 chickens suffering fromMD tumors were determined. The results showed that the activities of T-SOD (152. 45±11. 67 U/ml), Mn-SOD(64. 45±6. 07 U/ml) and CuZn-SOD (88. 01±8. 71 U/ml) in the serum and the activities of T-SOD (286. 01±68. 07 U/g) in the tumor tissues of chickens with MD respectively were significantly lower than those of the normal(P<0. 01), the activities of CAT (19. 3±3. 22 U/g) in Hb of red blood cell of chickens with MD were respectivelysignificantly lower than those of the normal (P<0. 05), the activity of GSH-Px of bled didn't show significant difference between MD chickens and healthy (P<0. 05), in contrast, the levels of MDA (4. 09±0. 76 nmol/ml) inserum of chickens with MD tumors were significantely higher (P<0. 01) than those of the normal. The present papersuggests that free radicals are involved in the developing process of MD tumor.
出处
《南京农业大学学报》
CAS
CSCD
北大核心
1995年第2期90-94,共5页
Journal of Nanjing Agricultural University
基金
高校博士点基金
关键词
马立克氏病
自由基
肿瘤
鸡病
chickens: March's disease
free radicals
tumor
