摘要
目的:探讨抑郁症患者睡眠生理结构的变化,并与正常人比较。方法:抑郁症组为2002-01/2004-12广州市精神病医院门诊抑郁症患者42例,正常对照组为广州市精神病医院部分职工和广州医学院部分学生,共选择30人。使用英国Oxford工厂生产的Medilog多导睡眠图记录仪进行多导睡眠图检查,记录整夜的脑电图信号。主要观察①睡眠进程:包括总记录时间,睡眠总时间,睡眠潜伏期,快速眼动睡眠潜伏等。②睡眠结构:包括各阶段(非快速眼动S1、S2、S3、S4、快速眼动)睡眠的时间和百分比,快速眼动活动度、密度和强度,睡后觉醒的次数、时间和百分比。③睡眠片断的平均时程。对此项检查获患者及家属全面知情同意。结果:抑郁症组及正常对照组均完成多导睡眠图的检查,全部进入结果分析。①睡眠进程分析:总记录时间两组无差异,抑郁症组睡眠总时间比正常对照组少,睡眠潜伏期比正常对照组长,快速眼动睡眠潜伏期比正常对照组短,差异均有显著性(P<0.05),抑郁症组睡眠效率和维持率低。②睡眠结构分析:抑郁症组非快速眼动S1时间比正常对照组长,但无统计学意义;非快速眼动S2时间比正常对照组短,[(212.72±22.9),(224.63±8.1)min,F=9.388,P=0.004];而非快速眼动(S3+S4)时间比正常组短,但无统计学意义,不少患者的整个慢波睡眠(S3+S4)缺失。抑郁症组快速眼动活动度、密度和强度均显著高于正常对照组,睡后觉醒时间长。③抑郁症组睡眠片断的平均时程低于正常对照组(81.90±7.2),(96.73±8.6)min,P=0.818。结论:抑郁症组睡眠潜伏期长、睡后觉醒时间长,睡眠效率和维持率低,快速眼动潜伏期缩短,S1睡眠延长,S3,S4睡眠缩短,部分患者的整个慢波睡眠(S3+S4)缺失。提示抑郁症患者与正常人有不同的睡眠模式,其睡眠障碍模式以快速眼动睡眠过度活跃为特征。
AIM： To explore the varieties of sleep physiology in patients with depression in comparison with normal people.METHODS： Forty-two patients with depression were selected from the Outpatient of Guangzhou Psychiatric Hospital from January 2002 through December 2004. They and their families all agreed to participate in the study. Twenty-five workers or students as normal eontrols were selected from Guangzhou Psychiatric Hospital and Guangzhou Medical College. Allnight physiological signals were recorded by Medilog Polysomnogram manufactured by Oxford Medical Limited. The main indexes were sleeping process, sleeping structure and average phase of sleeping fragment.RESULTS： All the subjects complete the examination and were involved in the result analysis. ① Sleeping process： There was no difference in the total recording time between the two groups. As compared with the normal group, total sleeping duration was shorter, sleeping latency was longer and latency of rapid eye movement sleep was shorted in the depression group （P 〈 0.05）. Depression group also had a lower sleeping efficiency and maintaining rate. ② Sleeping structure： Sleeping duration at stage St was longer in the depression group than in the control group, but there was no significant difference. Sleeping duration at stage S2 in the depression group was shorted than that in the control group [（212.72±22.9）, [224.63±8.1）minutes,F= 9.388,P= 0.004]. Sleeping duration at stage （S3＋S4） was shorted in the depression group,but there was also no difference between the two groups.Some patients had no slow wave sleep at stage （S3＋S4）.Activity, density and intensity of rapid eye movement in the depression group was higher as compared with the control group, and awaking duration was longer.③ The average phase of sleeping fragment was lower in the depression group as compared with the control group [181.90±7.2）,（96.73±8.6 ） minutes, P=- 0.818].CONCLUSION： The sleep pattern in patients with depression has the characteristics of hyperactive rapid eye movement sleep.
出处
《中国临床康复》
CSCD
北大核心
2005年第28期32-33,共2页
Chinese Journal of Clinical Rehabilitation
基金
广东省医学科研基金(A2001588)~~
