摘要
目的:探讨上皮性钙黏 素(E cd)及α 连接素(cat)、β cat在 浸润性乳腺癌中的表达及意义。 方法:免疫组化SP法。结果:60 例乳腺癌组织中E cd、α cat、β cat 异常表达率分别为51.7%、61.7% 和70%,E cd的表达与乳腺癌分 化程度、临床TNM分期、淋巴结 转移显著相关,P<0.005～ 0.0005,α cat、β cat的表达与分化 程度、淋巴结转移无关。如果将 E cd、α cat和β cat作为一类蛋白 分析,这类蛋白分子的异常表达与 淋巴结转移显著相关,P<0.05。 结论:E cd表达下调在乳腺癌浸 润、转移中有重要作用,E cd单独 表达下调足以破坏E cd/cat复合 物的功能,导致癌细胞浸润转移。
OBJECTIVE：To investigate proteins of E-cadherin and α-,β-catenin in invasive breast cancer and evaluate their possible role in breast cancer invasion and metastasis. METHODS： The high sensitive SP immunohistoehemical method was used to detect the protein expressions of E-cadherin and α-,β-catenin. RESULTS： The abnormal expression rates of E-cadherin,α-,β-catenin were 51.7%,61. 7% and 70% respectively among 60 cases of breast cancer. Abnormal E-cadherin and α-,β-catenin expressions were more often observed in invasive lobular carcinomas, P〈0. 025-0.01. The expression of E-eadherin showed a significant association with histological grade, tumor stage and lymphatic metastasis, P〈0.05- 0. 005. However, there was no significant relationship between α-,β-catenin staining and histological grade and lymph node status, When all of three proteins（E-cadherin, α-,β-catenin） were analysed as one group, a significant association was found between abnormal expression of at least one of these three proteins and the presence of lymphatic metastasis, P〈0.05. CONCLUSIONS：Down-regulation of E-cadherin may play a critical role in neoplastic cell invasion and metastasis in invasive breast cancer. Down-regulation of E-cadherin alone may be enough for the tumor cell to lose intercellular adhesion which results in tumor cell invasion and metastasis.
出处
《肿瘤防治杂志》
2005年第4期277-280,共4页
China Journal of Cancer Prevention and Treatment
基金
湖南省卫生厅资助项目(B2003-117)
