摘要
抗体酶是具有催化活性的免疫球蛋白,它既具有抗体的高效选择性,又能像酶那样高效催化化学反应,开创了催化剂研究的崭新领域.本文从抗体酶的作用机理、设计利制备、应用领域、存在的问题和研究展望等多个角度进行综述.
Abzyme is a kind of immunoglobulin with catalytic activity. It has not only high selectivity as antibodies but also highly catalytic activities as enzymes. It opens the new area of catalyst research. This article summarizes the mechanism, the design and manufacture methods, the applications, the existent problems and the research strategies of the abzyme.
基金
浙江大学城市学院科研计划项目(J56204052013)
关键词
抗体酶
半抗原设计
工程抗体催化
Abzyme
Hapten design
Engineering catalytic antibodies
