摘要
１２只健康小型猪，３０％Ⅲ度背部火焰烧伤，随机分成两组。Ａ组烧伤后复苏补液；Ｂ组除烧伤补液外，静注山莨菪碱每次用量０．４ｍｇ／ｋｇ体重，每日４次，共３ｄ。结果证实：胃肠粘膜血流量及组织氧合的恢复滞后于血流动力学参数（Ｐ＜０．０５）。烧伤后Ａ组门静脉内血浆ＤＡＯ和乳酸含量明显增加，ｐＨｉ降低，血培养阳性率增高。应用山茛菪碱后门静脉血流量增加，而血浆ＤＡＯ、乳酸和脏器细胞移位率明显降低。本研究结果显示：烧伤后可发生隐性代偿性休克，肠道持续血供不足可引起肠粘膜屏障的损伤，最终发生细菌移位。给予山茛菪碱对迅速恢复肠道血液循环具有保护作用，并可阻止细菌移位。
Twelve healthy midget pigs were used in the experiment. A 30%TBSAⅢflame burnwas produced on back of animals. The animals were randomly divided into two groups : Group A, burninjury with fluid resuscitation; group B, besides burn and resuscitation, anisodamine in a dose of 0.4mg/kg gid for 3 days。 The findings confirmed that the restoration of the gut mucosal blood flow and tissueoxygenation lagged behind systemic hemodynamic parameters(P< 0.05-0.01 ). In the group A therewere significant increases in both plasma DAO and lactic acid, lowering of pHi, decrease in portal flowand a higher incidence of positive portal blood culture, On the contrary, portal flow did not show signifi-cant decrease and it was significantly higher in group B, compared with group A. Plasma lactic acid inportal blood, plasma DAO and the rate of bacterial translocation were significantly lower in group B thangroup A. The resultsof this study demonstrated that there was a covert compensatory state after burn yn-jury, and bacterial translocation occurred consequent to damage to intestinal mucosal barrier due to com-promise of blood supply. The adrninistration of anisodamine was shown to have the effeet of restoring in-testinal circulation quickly, thus averting bacterial translocation.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1995年第2期88-91,共4页
Medical Journal of Chinese People's Liberation Army
关键词
烧伤
休克
细菌移位
粘膜内pH值
山莨菪碱
Burn
Covert compensatory shock
Bacterial translocation
Intramucosal pH
Aniso-
