摘要
目的研究不同剂量的阿托伐他汀对不稳定型心绞痛患者血清高敏C反应蛋白水平的影响。方法选取我院不稳定型心绞痛患者51例,随机分为小剂量组28例和大剂量组23例,分别给予阿托伐他汀10mg或40mg,每日1次。共用药30日,治疗前后分别测定患者血脂水平和血清高敏C反应蛋白水平。结果阿托伐他汀用药30日后,两组血脂水平和血清高敏C反应蛋白水平均明显降低,低剂量组从(17±6)μg/L降至(8.3±2.7)μg/L;高剂量组从(18±7)μg/L降至(8±3)μg/L。两组下降程度比较,差异有统计学意义。结论早期应用阿托伐他汀治疗不稳定型心绞痛,可减少斑块基质成分的降解和炎症反应,具有稳定斑块作用,使用大剂量阿托伐他汀的获益更多。
Objectives To study effects of difference doses of atorvastatin on plasma high sensitivity C-reactive protein （hs-CRP） levels in patients with unstable angina. Methods A total of 51 patients with unstable angina were divided into two groups group 1 had 28 patients and was given low dose of atorvastatin （10 mg a day）for 30 days and the group 2 had 23 patients and took large dose of atorvastatin（40 mg a day） for 30 days also. The serum levels of TC,TG,HDL-C,LDL-C were detected before and after therapy. Results 30 days later, the levels of TC,TG,HDL-C,LDL-C, hs-CRP decreased significantly and the decreasing degree had statistical differences between two groups （P〈0.05）. Conclusions Atorvastatin can decrease breakdown of matrix collagen,and inflammatory reaction in patients with acute coronary syndrome, especially in patients taken large doses.
出处
《岭南心血管病杂志》
2005年第4期262-264,共3页
South China Journal of Cardiovascular Diseases
