摘要
①目的探讨血管内皮生长因子(VEGF)在妊娠高血压综合征(妊高征)发病中的作用。②方法以免疫组织化学方法观察VEGF及其受体酪氨酸激酶-1(FLT-1)在正常妊娠及妊高征胎盘绒毛中的表达。③结果VEGF主要表达于胎盘绒毛滋养叶细胞;FLT-1在胎盘中表达于滋养叶细胞、绒毛间质和血管内皮细胞;妊高征组胎盘中VEGF、FLT-1的表达均较正常晚期妊娠组弱,差异有显著性(t=2.358、2.447,P<0.05)。④结论胎盘中VEGF及FLT-1表达的降低,可能致胎盘浅表着床,从而可能诱发妊高征。
Objective To explore the expression of vascular endothelial growth factor（VEGF） in the genesis of pregnancy-induced hypertension（PIH）. Methods Expressions of VEGF and its receptor FLT-1 were measured immunohistochemically in placental villi in women with normal pregnancy and PIH. Results VEGF was mainly expressed in the trephocytes of the placenta villi. FLT-1 was expressed in the trephocytes in normal term placenta, villous interstitial substance, and vascular endothelial cells. In PIH group, the distribution of VEGF and FLT-1 immunoreactivity was significantly reduced （t=2.358,2.447; P〈0.05）. Conclusion The reduced expression of VEGF and FLT-1 in placenta might lead to superficial implantation and the genesis of PIH.
出处
《青岛大学医学院学报》
CAS
2005年第2期146-148,共3页
Acta Academiae Medicinae Qingdao Universitatis
关键词
妊娠并发症
心血管
胎盘
血管内皮生长因子
受体
蛋白质酪氨酸激酶类
pregnancy complications, cardiovascular
placenta
vascular endothelial growth factor
receptor, proteintyrosine kinases
