摘要
目的:研究鞘内长时程联合应用吗啡和氯胺酮对神经痛大鼠痛行为的影响.方法:40只慢性神经痛大鼠随机分为5组,每组8只.B组:空白对照组;C组:鞘内给生理盐水10μl;K组:鞘内注射氯胺酮50μg;M组:鞘内注射吗啡20μg;KM组:鞘内注射吗啡10μg和氯胺酮25μg.术后4 d开始用药,每日1次,连续7 d.用药1d,连续观察热痛阈随时间的变化规律;每次用药后30 min测定热痛阈值,连续7 d.测量结果用最大镇痛效应百分率(MPE%)表示.结果:用药1 d,给药后90～120 min M组MPE%低于KM组(P＜0.01);K组MPE%在用药后30～120min之间低于M组和KM组(P＜0.01),在用药后15～45min之间高于C组(P＜0.01).用药后5～7 dM组MPE%低于KM组(P＜0.01).结论:吗啡和氯胺酮联合应用即减少吗啡的用量,又具有良好的抗伤害性作用,是治疗神经源性疼痛的有效途径.
Objective： To study the effect of long-term intrathecal coadministration morphine and ketamine on thermal thresholds in rats with chronic constriction injury, to the sciatic nerve. Methods： Forty Wistar rats were randomly divided into 5 groups （ n = 8） ： group C received 10μl saline, group M received 20μg morphine, group K received 50μg ketamine, group KM received 10 μg morphine and 25μg ketanfine, and group B as control. Drugs were administered from the 4th day after the sciatic nerve injury, once a day for 7 days. The effects of morphine and ketamine on thermal thresholds were determined as MPE%, the percentage of maximal possible effect. Results： On the 1 st day after the administration of drags, MPE% at 90 to 120 minutes in group M was significantly lower than that in group KM （ P 〈0.01）, and MPE% at 30 to 120 minutes in group K was lower than that in group M and group KM （ P 〈0.01）. The difference in MPE% was significant between group M and group KM on the 5th, 6th, and 7th day after the adnfinistration of drugs （ P 〈 0.01 ）.Conclusion： Intrathecal coadministration of morphine and ketamine is effective in treating neuralgia of rats, with the decreased dose of morphine。
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2005年第4期304-305,308,共3页
Journal of China Medical University
关键词
神经系统疾病
吗啡
氯胺酮
蛛网膜下腔
nervous system diseases
morphine
ketanline
subarachnoid cavity
