摘要
目的:评价中药配合血浆置换治疗重型肝炎的疗效。方法:将106例重型肝炎患者随机分为治疗组和对照组。治疗组56例(亚急性重型肝炎8例,慢性重型肝炎48例)在内科综合治疗基础上加用血浆置换及自拟中药方赤丹汤(由赤芍、丹参、麦芽、茯苓、金钱草、生地、猪苓、五味子、甘草等组成);对照组50例(亚急性重型肝炎6例,慢性重型肝炎44例)仅用内科综合治疗。结果:治疗组治疗后血清总胆红素由(482.0±132.6)μmol/L降至(251.6±143.2)μmol/L(P<0.01);丙氨酸转氨酶由(230.8±169.2)U/L降至(110.6±139.4)U/L(P<0.05);内毒素由(0.15±0.09)kEU/L降至(0.09±0.12)kEU/L(P<0.05);肿瘤坏死因子α由(1.59±0.58)μg/L降至(1.03±0.62)μg/L(P<0.01);白细胞介素6由(86.6±39.2)ng/L降至(39.5±20.6)ng/L(P<0.01);凝血酶原活动度由(28.5±15.2)%升高至(38.9±9.5)%(P<0.01);消化道症状改善,总有效率(治愈及好转)为76.8%,显著优于对照组40.0%(P<0.01)。结论:赤丹汤配合血浆置换是治疗重型肝炎的有效方法。
Objective： To evaluate the therapeutic effects of traditional Chinese medicine combined with plasma exchange in treatment of patients with severe hepatitis. Methods： One hundred and six patients with severe hepatitis were randomly divided into treatment group and control group. In the treatment group,56 patients with severe hepatitis （8 patients with subacute severe hepatitis, 48 patients with chronic severe hepatitis） received combined therapy of comprehensive internal medicine treatment, the artificial liver support system, and self- made traditional Chinese medicine Chidan decoction[赤丹汤, including radix paeoniae rubra（赤芍）, radix salviae miltiorrhizae （丹参）, fructus hordei germinatus （麦芽）, poria （茯苓）, herbalysimachiae （金钱草）, radix rehmanniae （生地）, polyporus umbellatus （ 猎苓 ）, fruct us schisandrae （ 五味子 ）,radix glycyrrhizae （甘草）, etc. ）. In the control group, 50 cases were treated with comprehensive internal medicine alone. Results： After treatment, in the treatment group serum total billirubin decreased from （482.0±132.6） /μmol/L to （ 251.6±143.2 ）/μmol/L （P 〈 0.01 ）, alanine aminotransferase decreased from（230.8＋169.2）U/L to （110.6±139.4）U/L（P〈0. 05）, endotoxin decreased from （0.15±0.09）kEU/L to（0.09±0. 12）kEU/L（P〈0.05）, tumor necrosis factor-α （TNF-α） decreased from （1.59±0.58）μg/L to（1.03±0.62）/μg/L（P〈0.01）, interleukin - 6 decreased from （86.6±39.2）ng/L to （39.5±20.6）ng/L（P〈0.01）, prothrombin activity （PTA） increased from （28.5±15.2）% to （38.9＋9.5）%（P〈0.01）, and the symptoms of digestive tract were improved. The total effective rate （cured and improved） was 76.8% in the treatment group, and it was superior to that in the control group（40.0%, P〈0. 01）. Conclusion： Chidan decoction combined with plasma exchange is an effective method for treating severe hepatitis.
出处
《中国中西医结合急救杂志》
CAS
2005年第4期227-229,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
贵州省黔南州科技计划项目资助(2003291)
