摘要
目的探讨一氧化氮和一氧化氮合酶是否参与了急性脑缺血再灌注的发病机制。方法采用栓线法复制大鼠大脑中动脉阻塞模型,观察血清及脑组织NO含量和NOS活性的变化。结果脑缺血45min再灌注2h后血清及脑组织中NO含量及NOS活性增加,再灌注8h达高峰。结论NO及NOS在急性脑缺血再灌注的过程中起着重要的作用。
Objective To study whether nitric oxide and Nosynthase were involved in the pathogenesis of acute cerebral ischemia reperfusion. Methods Using rat model of a middle cerebral artery occlusion by suture,NO content and NOS activity in brain and serum during reperfusion. Results The NO content and NOS activity in brain tissue and serum increased at 2h of reperfusion after 45 min of ischemia,They reched peak at 8h of reperfusion .Conclusion NO and NOS may play an important role in acute cerebral ischemia reperfusion.
