摘要
用丙酮、二氰二胺和取代苯胺三组分法合成了９个新的１－取代苯基三嗪类化合物。测定了它们的抗癌活性，３，４，７有抑制人白血病ＨＬ－６０细胞的作用，人鼻咽癌ＫＢ细胞可被２，５，７抑制。
ine novel l-substituted phenyl triazine compounds were synthesized in the three-component acetone,substi-tuted aniline and dicyandiamide method. Their activities of anticancer were determined. 3,4,7 had inhibitory ac-tions to human leukemia HL-60 cells. Human NPC(nasopharyngeal carcinoma)KB cells had been inhibited by 2,5,
出处
《北京医科大学学报》
CSCD
1995年第3期233-235,共3页
Journal of Peking University(Health Sciences)
基金
国家自然科学基金
关键词
氨甲喋呤
化学合成
取代苯基三嗪
药理学
抗癌药
Headings Methotrexate/chem syn
Antineoplastic agents/chem syn
Antineoplastic agents/phar-macol
l-substituted phenyl triazine
