摘要
本文采用３２Ｋｇ重物挤压家兔双后肢的大腿和臀部５小时，复制出挤压伤的动物模型，在此基础上观察了解压后２４小时反映组织细胞损伤的血浆ＭＤＡ、ＮＡＧ及反映器官功能指标的血浆ＧＰＴ、肌酐、尿ＮＡＧ和肺通透指数变化，并分别用自由基清除剂ＣｏＱ１０和甘露醇于挤压前和解压前５分钟静脉注射，观察其对挤压伤的治疗作用。实验结果显示，挤压伤后血浆ＭＤＡ、ＮＡＧ显著性升高、心，肝、肺、肾、小肠和骨骼肌组织ＭＤＡ显著性增高，肝、肺、肾等器官功能明显降低，应用ＣｏＱ１０和甘露醇显示出减轻组织损伤保护器官功能的作用，但两者间没有明显差异。本文认为，ＣｏＱ１０和甘露醇可能通过抗自由甚途径对挤压伤后多器官功能损害起保护作用。
We attemptei to reproduce an animal model of multiple orgn injury after crushed injury and the protective effect of CoQ10 and mannitol was atudied in rabbits.The hindlimbs were crushed by 32 kg weight of stone 5 hours before and after being.Crushed 5ml/kg of CoQ10,0.4mg/ml of mannitol(20%)were injected respectively MDA、NAG、Cr、GPT、protein in plasma,NAG.Cr were measured in urein, MDA in lung,livet,kidney、intestine、musele.The regults showed:the protective effect of CoQ10 and mannitol on multiple organ injurg,but no significant differenes between CoQ10 and mannitol in multiple organ injurg.It was considered that the protective(mechanism)of CoQ10 and mannitol may be due to itsantioxid ativeactivity
出处
《锦州医学院学报》
1995年第3期17-19,共3页
Journal of Jinzhou Medical College
基金
煤炭优秀青年科学基金
