摘要
通过动态监测３６例肾移植患者血中白介素－１（ＩＬ－１）、白介素－６（ＩＬ－６）、肿瘤坏死因子－α（ＴＮＦ－α）水平变化，发现急性排斥（ＡＲ）发生前１～３天，上述因子水平有不同程度的升高，峰值水平均在抗排斥治疗日出现．ＩＬ－１、ＩＬ－６、ＴＮＦ－α水平在急性感染发生时也有不同程度的升高，而在急性肾小管坏死（ＡＴＮ）发生时则不升高．此外，ＡＲ组患者术后第一周ＩＬ－１、ＴＮＦ－α水平比其他组要高．结果表明：动态监测上述因子水平变化有助于预测和早期诊断ＡＲ发生，对鉴别诊断ＡＲ和ＡＴＮ有重要帮助．
With the sequential determinations of blood levels of interleukin-1 (IL-1). interleukin-6(IL-6 ) and tumor necrosis factor-alpha (TNF-α)in 36 renal allograft recipients, it was found that the levels of the above cytokines rised 1～3days before the diagnosis of acute rejection(AR)and that the peak levels appeared at the day of clinical diagnosis of AR, Elevation of the above cytokine levels were also found in infectious episodes,but not in acute tubular necrosis ( ATN). Besdes, rejection group displayed higher levels of IL-1 and TNF-αin the first posttransplant week than the others. The above results showed that sequential determinations of Hood IL-1 IL-6 and TNF-α levels would be helpful in the early diagnosis of AR as well as the differential diagnosis between AR and ATN.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
1995年第5期277-279,共3页
Chinese Journal of Urology
