摘要
报道鳖甲浸出液对人肠癌细胞系（ＨＲ－８３４８）的体外实验，分别从细胞抑制率、细胞集落形成率、细胞上清液中ＬＤＨ活性的测定，光、电镜下的细胞形态观察，探讨了鳖甲对人肠癌的作用机理。初步结果表明：单纯鳖甲２ｇ／Ｌ浓度以上对肠癌细胞有抑制生长作用，鳖甲加氟脲嘧啶联合用药对肠癌细胞的抑制生长作用较单纯氟脲嘧啶更显著。这一实验结果将为临床应用鳖甲抗肠癌治疗提供了实验依据，并提示：鳖甲加氟脲嘧啶联合用药对肠癌的治疗效果更佳，充分显示了协同抗癌作用。
In this study,cellular survival count,mitotic index, LDH level in the culture fluid,efficiency of colony formation, microscope and transmission electron microscope examination were used to investigate the toxic effect on human rectum adenocarcinoma cells(HR-8348). The results showed that turtle carapace powder(TCP)>2g/L alone had inhibition effect on human rectum adenocarcinoma cells.The usage of combination of TCP and 5Fu had stronger effect than that of 5Fu alone(P<0.001).The result of this study provided an experimental basis for the clinical use in the treatment on rectal adenocarcinoma.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1995年第2期146-149,共4页
Chinese Journal of Clinical Oncology
关键词
鳖甲
浸出液
HR-3838
人肠癌细胞
毒性
Aqueous Extract
Turtle's carapace
HR-8348
Adenocarcinoma cell line
Toxic effect
