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蛋白酶体抑制剂MG132诱导肿瘤细胞凋亡机制的研究进展 被引量：10

Advances in the Research of Mechanism of Apoptosis of Tumorous Cells Induceded by Proteasome Inhibitor MG132
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摘要 MG132(Z-Leu-Leu-Leu-CHO)是一种蛋白酶体抑制剂,能进入细胞中可逆性地抑制蛋白酶体的活性,从而抑制泛素—蛋白酶体通路所介导蛋白质的降解,进而影响细胞周期进程和诱导细胞凋亡。目前,许多文献报道MG132能够诱导多种肿瘤细胞发生凋亡,是一种潜在的抗肿瘤药物。 MG132 (Z-Leu-Leu-Leu-CHO) is an inhibitor of proteasome, and it can enter the cell to reversibly inhibit the activation of proteasome, thereby influencing the course of cell cycle and inducing the apoptosis of cells. Currently, it has been reported that MG132 can induce apoptosis of all kinds of tumorous cells and can be used a anti-tumor drug. This article reviews the mechanisms of the apoptosis of the tumorous cells induced by MG132.
作者 饶敏 张淑玲 熊莉娟
机构地区 华中科技大学同济医学院附属协和医院传染科
出处 《医学分子生物学杂志》 CAS CSCD 2005年第4期298-301,共4页 Journal of Medical Molecular Biology
关键词 蛋白酶体抑制剂 细胞凋亡机制 诱导细胞凋亡 细胞周期进程 抗肿瘤药物 进入细胞 细胞发生 多种肿瘤 文献报道 可逆性 蛋白质 MG132 proteasome inhibitor tumor
分类号 R979.1 [医药卫生—药品] R378.25 [医药卫生—病原生物学]
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参考文献15

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  • 2Munshi A, Kurland JF, Nishikawa T, et al. Inhibition of constitutively activated nuclear factor-kappaB radiosensitizes human melanoma cells. Mol Cancer Ther, 2004, 3(8): 985-92.
  • 3孙国敬,钱俊杰,孟祥兵,宋宜,张枫,梅柱中,董燕,孙志贤.蛋白酶体抑制剂MG132诱导HL-60细胞凋亡前G_2/M期阻滞及机制[J].癌症,2004,23(10):1144-1148. 被引量：12
  • 4Kim OH, Lim JH, Woo KJ, et al. Influence of p53 and p21Waf1 expression on G2/M phase arrest of colorectal carcinoma HCT116 cells to proteasome inhibitors. Int J Oncol, 2004, 24 (4): 935-41.
  • 5Emanuele S, Calvaruso G, Lauricella M, et al. Apoptosis induced in hepatoblastoma HepG2 cells by the proteasome inhibitor MG132 is associated with hydrogen peroxide production, expression of Bcl-XS and activation of caspase-3.Int J Oncol, 2002, 21 (4): 857-65.
  • 6Bang JH, Han ES, Lim I, et al. Differential response of MG132 cytotoxicity against small cell lung cancer cells to changes in cellular GSH contents. Biochem Pharmacol,2004, 68 (4) ; 659-66.
  • 7Lu M, Kitson RP, Xue Y, et al. Activation of multiple caspases and modification of cell surface fas (CD95) in proteasome inhibitor-induced apoptosis of rat natural killer cells. J Cell Biochem, 2003, 88 (3): 482-92.
  • 8Meli M, D'Alessandro N, Tolomeo M, et al. NF-κB inhibition restores sensitivity to Fas-mediated apoptosis in lymphoma cell lines. Ann NY Acad Sci, 2003, 10 (10): 232-6.
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二级参考文献8

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  • 8董波,陈肖华,张浩,张军权,罗庆良,史莲萍,毛秉智.一种改进的用于测定细胞周期的细胞制备方法[J].军事医学科学院院刊,2002,26(2):124-126. 被引量：31

共引文献11

同被引文献107

引证文献10

二级引证文献23

医学分子生物学杂志
2005年 第4期

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