摘要
本文检测了８０例乙型肝炎后肝硬化患者和６０例健康人血清透明质酸（ＨＡ），用自拟抗纤方为基本方，观察治疗后血清ＨＡ的变化，探讨血清ＨＡ与辨证施治之间的关系。结果显示，肝硬化患者血清ＨＡ显著高于健康人（Ｐ＜０．０１）；ＨＡ水平与中医证型密切相关，其变化规律为热血淤型＞气滞血淤型＞肝郁脾虚型＞正常对照组，证型之间差异显著（Ｐ＜０．０５～０．０１）。提示血清ＨＡ可作为乙型肝炎后肝硬化中医辨证分型、判断病情及预后，指导治疗的客观指标之一。经抗纤方加减治疗，ＨＡ水平显著下降（Ｐ＜０．０１），肝功能得到显著改善（Ｐ＜０．０１），证明该方不但能有效地改善肝脏功能，而且具有显著的抗纤维化的作用。
The serum HA level were detected in the 80 patients with cirrhosis after hepatitis Band 60 normal human. The results showed that the serum HA level in cirrhosis was markedly higher than that in the normal human (P<0. 01);serum HV level was closely associated with the syndromes of TCM and in turn heat stagnation and blood stasis group >qi stagnation and blood stasisgroup >liver-qi deprrssion and spleen deficiency group>normal eontrol group (P<0. 05-0. 01 ).These patient were treated by anty-fibrosis decoction,their serum HA level apparently decreasedand the liver function obviously improved(p<0. 01 ). All results manifested the serum HA levelcan serve as a objective index for the making a difference in syndromes of TCM,judging patientcondition and prognosis,and guiding treatment; the anty-fibrosis decoction has a better curativeeffect for improving liver function and anty-liver fibrosis.
关键词
透明质酸
抗纤方
肝硬变
中医药疗法
辨证论治
Hepatitis B with cirrhosis HA Anty-liver fibrosis decoction Syndrome differentiation of TCM
