摘要
目的应用组织多普勒成像(TDI)技术测量室间隔、侧壁等的舒张、收缩速度,评价美托洛尔对左室舒张功能的影响。方法原发性高血压(EH)左室肥厚患者23例,在服用美托洛尔2mg·kg-1·d-1前后,用TDI法分别测其二尖瓣环水平间隔、侧壁、前壁、下壁的收缩期峰值速度(Sm),舒张早期峰值速度(Em),舒张晚期峰值速度(Am),比较用药前后各部位Em/Am比值。结果服用美托洛尔3个月后,患者舒张功能均有明显改善。EH组左室各部位心肌Em增大,Am减少,Em/Am均明显提高。结论美托洛尔能够改善肥厚心肌的舒张功能,二尖瓣环水平的Em、Am的测定能克服二尖瓣血流的假性正常化,对用药后的变化也能够敏感地表现出来,可作为定量无创评价左室舒张功能的良好指标。
Objective:In order to define the clinic value of tissue Doppler imaging (TDI), we used TDI technic to compare the diastolic and systolic motion velocities of left ventricular septum and lateral wall before and after being treated with metoprolol. Method:Twenty-three patients with essential hypertension (EH) accompanying left venbtricular hypertrophy were enrolled in the study. By using TDI, we measured the peak systolic(Sm), peak early diastolic(Em), peak end diastolic motion velocity(Am) and Em/Am of left ventricular septum at mitral valve level, lateral wall and posterior wall individually before and after being treated with metoprolol (2 mg·kg -1 ·d -1 ). Result:Diastolic function was significantly improved after treatment of metoprolol for 3 months in EH patients. Whereas Em was obviously increased, Am was decreased, and Em/Am was increased significantly of left ventricle in EH patients. Conclusion:TDI is valuable in diagnose of the diastolic function improvement treated with motoprolol in patients with hypertrophic heart.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2005年第7期408-410,共3页
Journal of Clinical Cardiology
关键词
心室功能
左
超声心动描记术
多普勒
美托洛尔
Hypertension
Ventricular function,left
Echocardiography, Doppler
Metoprolol
