摘要
目的探讨尿微量蛋白测定对窒息新生儿肾脏损害早期诊断价值。方法对重度窒息组新生儿24例、轻度窒息组新生儿26例和31名正常新生儿(对照组)进行尿免疫球蛋白(IgG)、转铁蛋白(TRF)、白蛋白(Alb)、α1微球蛋白(α1-MG)和血肌酐(Cr)检测。结果尿微量蛋白重度窒息组均高于轻度窒息组和对照组(均P<0.01),血Cr水平3组间差别无显著性意义(P>0.05)。重度窒息组新生儿尿微量蛋白测定异常率高于轻度窒息组新生儿(均P<0.01和0.05),而血Cr水平异常率两组比较差别无显著性意义(P>0.05)。结论尿微量蛋白测定对新生儿窒息肾功能损害有一定的早期评估价值。
Objective To explore the diagnostic value of measuring microproteinuria in renal injury of the asphyxia infants. Methods Four urinary minimal proteins - immunoglobulin G IgG. transferrin TRF albumin Alb α1-microglobulin α1-MG as well as serum creatinineCr were measured in 24 severe asphyxia infants26 mild asphyxia infants and 31 normal infants. Results The urinary levels of 4 measured proteins were higher in severe asphyxia group than those in mild asphyxia group and the normal controls P<0.01 while there was no significant difference in serum Cr levels P>0.05. The rate of microproteinuria was higher in severe asphyxia infants than that in mild asphyxia infants P<0.01 while there was no significant difference in rate of high serum Cr P>0.05 . Conclusion Measurements of urine four minimal proteins have early diagnostic value to evaluate injuries of asphyxia infants'renal funcation.
出处
《浙江医学》
CAS
2005年第7期499-500,511,共3页
Zhejiang Medical Journal
