摘要
探讨铁蛋白ferrztin,Ft在鉴别胸腹液良、恶性质的临界值。用RIA法测定218份由不同病因引起的胸腹液标本铁蛋白(pleuraleffusionferritin,PFt)及其同期血清铁蛋白(SFt)。依据临床确诊资料,将标本进行良、恶性病例分组,比较两组PFt、SFt,计算PFt/SFt比值,用ROC曲线选择PFt用于良、恶性质鉴别的最佳临界值。结果表明,良性组PFt为142.4±38.6μg/L,SFt为89.7±43.5μg/L,PFt/SFt为1.46±0.55;恶性组PFt为576.5±239.1μg/L,SFt为189.6±81.7μg/L,PFt/SFt为3.67±1.48;PFt用于鉴别胸腹液良、恶性质的临界值为400μg/L。以恶性积液PFt≥400μg/L、PFt/SFt≥3,良性积液PFt<400μg/L、PFt/SFt<3为实验诊断标准鉴别胸腹腔积液的良、恶性质,灵敏度为84.5%、特异性为87.5%,准确性为92.8%。
To explore the levem of ferritin for differentiating the benign from malignant pleural and peritoneal effusion, 218 pleural-peritoneal effusion samples from patients with different kinds of diseases were determined for ferritin(P_ Ft ) by RIA, in the meanwhile serum ferritin(S_ Ft ) was also determined. According to clinical diagnosis, these samples were divided into two groups:benign and malignant.P_ Ft and S_ Ft were compared between these two groups, and the ratio of P_ Ft to S_ Ft was counted. The ROC curve was used to choose the best cut-off point P_ Ft for differentiating benign from malignant pleural and peritoneal effusion. The results showed that in the benign effusion group the P_ Ft was 142.4±38.6 μg/L,S_ Ft was 89.7±43.5μg/L, and P_ Ft /S_ Ft was 1.46±0.55, whereas in the group of malignant effusion the corresponding figures were 576.5±239.1μg/L, 189.6±81.7μg/L, and 3.67±1.48, respectively. The cut-off point for differentiating benign from malignant pleural and peritoneal effusion was 400 μg/L. Our diffe- rentiation standards are: P_ Ft ≥400 μg/L,P_ Ft /S_ Ft ≥3 for the malignant pleural and peritoneal effusion, and P_ Ft <400 μg/L,P_ Ft /S_ Ft <3 for the benign effusion. The sensitivity is 84.5%, the specificity is 87.5%, and the accuracy is 92.8%.
出处
《标记免疫分析与临床》
CAS
2005年第2期84-86,共3页
Labeled Immunoassays and Clinical Medicine
关键词
铁蛋白ROC曲线
胸腹液良恶性质
临界值
Ferritin
ROC curve
The benign or malignant pleural-peritonreal effusion
Cut-off point
