摘要
对６００例闭经≤４９天早孕健康妇女分别使用单次口服２００ｍｇ或１５０ｍｇ米非司酮后，第三天口服米索前列醇６００μｇ的临床随机对比。结果：两组流产效果相似，完全流产率分别为９３．４％和９２．３％；不全流产率分别为３．３％和３．０％；失败率分别为３．３％和４．７％。绒毛胎囊排出时间、流产后出血和月经恢复情况两组相似。本资料提示，采用米非司酮单次口服１５０ｍｇ后第三天加服米索前列醇６００μｇ，是一种高效、简便、副反应少的药物流产方法。
Six hundred early pregnant women with amenorrhea≤49 days were ramdomized intotwo groups,one group using 200mg and another using l50mg mifepristone Both groups were given600μg misoprostol on day 3. The efficacy of two groups were similar.The complete abortion rates were93.4%and 92.3%, the incomplete abortion rates were 3.3% and 3.0% and the failure rates were 3.3%and 4.7%, respectively.The percentages of passing the villi and sac within 3hrs and 6hrs for 200mg groupwere 63.2% and 89.2%, the mean time was 3.8 ± 6.7 hrs.For the l50mg group they were 58.5% and92.3% and the mean time was 3.7 ± 5.l hrs.The bleeding pattern,including days (around 16 days) andamount after abortion and the time for recovery of menstruation(around 37 days)for both groups weresimilar(p>0.05).These data suggested that mifepristone l50mg in a single dose combined withmisoprostol 600μg on day 3 was a simple, low cost and low side-effects method for termination of earIy pregnancy.
出处
《生殖医学杂志》
CAS
1994年第4期199-201,共3页
Journal of Reproductive Medicine
关键词
米非司酮
前列腺素
终止妊娠
Mifepristone Prostaglandins Aboftion,induce
